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Mechanisms of propranolol action in infantile hemangioma
Infantile hemangioma is a common tumor of infancy. Although most hemangiomas spontaneously regress, treatment is indicated based on complications, risk to organ development and function, and disfigurement. The serendipitous discovery of propranolol, a non-selective β-adrenergic receptor blocker, as...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580045/ https://www.ncbi.nlm.nih.gov/pubmed/26413184 http://dx.doi.org/10.4161/19381980.2014.979699 |
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author | Kum, Jina JY Khan, Zia A |
author_facet | Kum, Jina JY Khan, Zia A |
author_sort | Kum, Jina JY |
collection | PubMed |
description | Infantile hemangioma is a common tumor of infancy. Although most hemangiomas spontaneously regress, treatment is indicated based on complications, risk to organ development and function, and disfigurement. The serendipitous discovery of propranolol, a non-selective β-adrenergic receptor blocker, as an effective means to regress hemangiomas has made this a first-line therapy for hemangioma patients. Propranolol has shown remarkable response rates. There are, however, some adverse effects, which include changes in sleep, acrocyanosis, hypotension, and hypoglycemia. Over the last few years, researchers have focused on understanding the mechanisms by which propranolol causes hemangioma regression. This has entailed study of cultured vascular endothelial cells including endothelial cells isolated from hemangioma patients. In this article, we review recent studies offering potential mechanisms of how various cell types found in hemangioma may respond to propranolol. |
format | Online Article Text |
id | pubmed-4580045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-45800452015-09-25 Mechanisms of propranolol action in infantile hemangioma Kum, Jina JY Khan, Zia A Dermatoendocrinol Review Infantile hemangioma is a common tumor of infancy. Although most hemangiomas spontaneously regress, treatment is indicated based on complications, risk to organ development and function, and disfigurement. The serendipitous discovery of propranolol, a non-selective β-adrenergic receptor blocker, as an effective means to regress hemangiomas has made this a first-line therapy for hemangioma patients. Propranolol has shown remarkable response rates. There are, however, some adverse effects, which include changes in sleep, acrocyanosis, hypotension, and hypoglycemia. Over the last few years, researchers have focused on understanding the mechanisms by which propranolol causes hemangioma regression. This has entailed study of cultured vascular endothelial cells including endothelial cells isolated from hemangioma patients. In this article, we review recent studies offering potential mechanisms of how various cell types found in hemangioma may respond to propranolol. Taylor & Francis 2015-01-26 /pmc/articles/PMC4580045/ /pubmed/26413184 http://dx.doi.org/10.4161/19381980.2014.979699 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kum, Jina JY Khan, Zia A Mechanisms of propranolol action in infantile hemangioma |
title | Mechanisms of propranolol action in infantile hemangioma |
title_full | Mechanisms of propranolol action in infantile hemangioma |
title_fullStr | Mechanisms of propranolol action in infantile hemangioma |
title_full_unstemmed | Mechanisms of propranolol action in infantile hemangioma |
title_short | Mechanisms of propranolol action in infantile hemangioma |
title_sort | mechanisms of propranolol action in infantile hemangioma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580045/ https://www.ncbi.nlm.nih.gov/pubmed/26413184 http://dx.doi.org/10.4161/19381980.2014.979699 |
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