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Mechanisms of propranolol action in infantile hemangioma

Infantile hemangioma is a common tumor of infancy. Although most hemangiomas spontaneously regress, treatment is indicated based on complications, risk to organ development and function, and disfigurement. The serendipitous discovery of propranolol, a non-selective β-adrenergic receptor blocker, as...

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Detalles Bibliográficos
Autores principales: Kum, Jina JY, Khan, Zia A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580045/
https://www.ncbi.nlm.nih.gov/pubmed/26413184
http://dx.doi.org/10.4161/19381980.2014.979699
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author Kum, Jina JY
Khan, Zia A
author_facet Kum, Jina JY
Khan, Zia A
author_sort Kum, Jina JY
collection PubMed
description Infantile hemangioma is a common tumor of infancy. Although most hemangiomas spontaneously regress, treatment is indicated based on complications, risk to organ development and function, and disfigurement. The serendipitous discovery of propranolol, a non-selective β-adrenergic receptor blocker, as an effective means to regress hemangiomas has made this a first-line therapy for hemangioma patients. Propranolol has shown remarkable response rates. There are, however, some adverse effects, which include changes in sleep, acrocyanosis, hypotension, and hypoglycemia. Over the last few years, researchers have focused on understanding the mechanisms by which propranolol causes hemangioma regression. This has entailed study of cultured vascular endothelial cells including endothelial cells isolated from hemangioma patients. In this article, we review recent studies offering potential mechanisms of how various cell types found in hemangioma may respond to propranolol.
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spelling pubmed-45800452015-09-25 Mechanisms of propranolol action in infantile hemangioma Kum, Jina JY Khan, Zia A Dermatoendocrinol Review Infantile hemangioma is a common tumor of infancy. Although most hemangiomas spontaneously regress, treatment is indicated based on complications, risk to organ development and function, and disfigurement. The serendipitous discovery of propranolol, a non-selective β-adrenergic receptor blocker, as an effective means to regress hemangiomas has made this a first-line therapy for hemangioma patients. Propranolol has shown remarkable response rates. There are, however, some adverse effects, which include changes in sleep, acrocyanosis, hypotension, and hypoglycemia. Over the last few years, researchers have focused on understanding the mechanisms by which propranolol causes hemangioma regression. This has entailed study of cultured vascular endothelial cells including endothelial cells isolated from hemangioma patients. In this article, we review recent studies offering potential mechanisms of how various cell types found in hemangioma may respond to propranolol. Taylor & Francis 2015-01-26 /pmc/articles/PMC4580045/ /pubmed/26413184 http://dx.doi.org/10.4161/19381980.2014.979699 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kum, Jina JY
Khan, Zia A
Mechanisms of propranolol action in infantile hemangioma
title Mechanisms of propranolol action in infantile hemangioma
title_full Mechanisms of propranolol action in infantile hemangioma
title_fullStr Mechanisms of propranolol action in infantile hemangioma
title_full_unstemmed Mechanisms of propranolol action in infantile hemangioma
title_short Mechanisms of propranolol action in infantile hemangioma
title_sort mechanisms of propranolol action in infantile hemangioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580045/
https://www.ncbi.nlm.nih.gov/pubmed/26413184
http://dx.doi.org/10.4161/19381980.2014.979699
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