Right on TARGET: glutamine metabolism in cancer

Recent studies highlight the importance of glutamine metabolism in metabolic reprogramming, which underlies cancer cell addiction to glutamine. Examples for the dependence on glutamine metabolism are seen across different tumor types as during different phases of cancer development, progression and...

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Detalles Bibliográficos
Autores principales: Ratnikov, Boris, Jeon, Young Joo, Smith, Jeffrey W., Ronai, Ze'ev A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580059/
https://www.ncbi.nlm.nih.gov/pubmed/26425657
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author Ratnikov, Boris
Jeon, Young Joo
Smith, Jeffrey W.
Ronai, Ze'ev A.
author_facet Ratnikov, Boris
Jeon, Young Joo
Smith, Jeffrey W.
Ronai, Ze'ev A.
author_sort Ratnikov, Boris
collection PubMed
description Recent studies highlight the importance of glutamine metabolism in metabolic reprogramming, which underlies cancer cell addiction to glutamine. Examples for the dependence on glutamine metabolism are seen across different tumor types as during different phases of cancer development, progression and response to therapy. In this perspective, we assess the possibility of targeting glutamine metabolism as a therapeutic modality for cancer.
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spelling pubmed-45800592015-09-30 Right on TARGET: glutamine metabolism in cancer Ratnikov, Boris Jeon, Young Joo Smith, Jeffrey W. Ronai, Ze'ev A. Oncoscience Research Perspective Recent studies highlight the importance of glutamine metabolism in metabolic reprogramming, which underlies cancer cell addiction to glutamine. Examples for the dependence on glutamine metabolism are seen across different tumor types as during different phases of cancer development, progression and response to therapy. In this perspective, we assess the possibility of targeting glutamine metabolism as a therapeutic modality for cancer. Impact Journals LLC 2015-08-20 /pmc/articles/PMC4580059/ /pubmed/26425657 Text en Copyright: © 2015 Ratnikov et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Ratnikov, Boris
Jeon, Young Joo
Smith, Jeffrey W.
Ronai, Ze'ev A.
Right on TARGET: glutamine metabolism in cancer
title Right on TARGET: glutamine metabolism in cancer
title_full Right on TARGET: glutamine metabolism in cancer
title_fullStr Right on TARGET: glutamine metabolism in cancer
title_full_unstemmed Right on TARGET: glutamine metabolism in cancer
title_short Right on TARGET: glutamine metabolism in cancer
title_sort right on target: glutamine metabolism in cancer
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580059/
https://www.ncbi.nlm.nih.gov/pubmed/26425657
work_keys_str_mv AT ratnikovboris rightontargetglutaminemetabolismincancer
AT jeonyoungjoo rightontargetglutaminemetabolismincancer
AT smithjeffreyw rightontargetglutaminemetabolismincancer
AT ronaizeeva rightontargetglutaminemetabolismincancer

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