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Cytomegalovirus infection can mimic genetic nephrotic syndrome: a case report
BACKGROUND: Nephrotic syndrome is a relatively rare but serious condition in children. Infantile nephrotic syndrome often has a genetic origin; the treatment is then symptomatic, with a poor prognosis, and a rapid evolution to chronic kidney disease. However, non-genetic infantile nephrotic syndrome...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580224/ https://www.ncbi.nlm.nih.gov/pubmed/26395882 http://dx.doi.org/10.1186/s12882-015-0152-z |
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author | Hogan, Julien Fila, Marc Baudouin, Véronique Peuchmaur, Michel Deschênes, Georges Niel, Olivier |
author_facet | Hogan, Julien Fila, Marc Baudouin, Véronique Peuchmaur, Michel Deschênes, Georges Niel, Olivier |
author_sort | Hogan, Julien |
collection | PubMed |
description | BACKGROUND: Nephrotic syndrome is a relatively rare but serious condition in children. Infantile nephrotic syndrome often has a genetic origin; the treatment is then symptomatic, with a poor prognosis, and a rapid evolution to chronic kidney disease. However, non-genetic infantile nephrotic syndrome has been identified. Here we report for the first time in a child a nephrotic syndrome as the sole clinical expression of a cytomegalovirus infection. CASE PRESENTATION: The patient was 5 months old when he presented with a nephrotic syndrome. An exhaustive genetic testing was conducted and came back negative. A viral work-up only showed a positive cytomegalovirus PCR. Antiviral treatment lead to a complete remission of the nephrotic syndrome, with no requirement for steroid therapy. Renal function remained normal throughout follow-up. CONCLUSION: Nephrotic syndrome should always be carefully investigated in children. This observation reinforces the connection between viral infections and pediatric nephrotic syndrome, sparking more controversy about an infectious origin to childhood nephrotic disease. |
format | Online Article Text |
id | pubmed-4580224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45802242015-09-24 Cytomegalovirus infection can mimic genetic nephrotic syndrome: a case report Hogan, Julien Fila, Marc Baudouin, Véronique Peuchmaur, Michel Deschênes, Georges Niel, Olivier BMC Nephrol Case Report BACKGROUND: Nephrotic syndrome is a relatively rare but serious condition in children. Infantile nephrotic syndrome often has a genetic origin; the treatment is then symptomatic, with a poor prognosis, and a rapid evolution to chronic kidney disease. However, non-genetic infantile nephrotic syndrome has been identified. Here we report for the first time in a child a nephrotic syndrome as the sole clinical expression of a cytomegalovirus infection. CASE PRESENTATION: The patient was 5 months old when he presented with a nephrotic syndrome. An exhaustive genetic testing was conducted and came back negative. A viral work-up only showed a positive cytomegalovirus PCR. Antiviral treatment lead to a complete remission of the nephrotic syndrome, with no requirement for steroid therapy. Renal function remained normal throughout follow-up. CONCLUSION: Nephrotic syndrome should always be carefully investigated in children. This observation reinforces the connection between viral infections and pediatric nephrotic syndrome, sparking more controversy about an infectious origin to childhood nephrotic disease. BioMed Central 2015-09-22 /pmc/articles/PMC4580224/ /pubmed/26395882 http://dx.doi.org/10.1186/s12882-015-0152-z Text en © Hogan et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Hogan, Julien Fila, Marc Baudouin, Véronique Peuchmaur, Michel Deschênes, Georges Niel, Olivier Cytomegalovirus infection can mimic genetic nephrotic syndrome: a case report |
title | Cytomegalovirus infection can mimic genetic nephrotic syndrome: a case report |
title_full | Cytomegalovirus infection can mimic genetic nephrotic syndrome: a case report |
title_fullStr | Cytomegalovirus infection can mimic genetic nephrotic syndrome: a case report |
title_full_unstemmed | Cytomegalovirus infection can mimic genetic nephrotic syndrome: a case report |
title_short | Cytomegalovirus infection can mimic genetic nephrotic syndrome: a case report |
title_sort | cytomegalovirus infection can mimic genetic nephrotic syndrome: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580224/ https://www.ncbi.nlm.nih.gov/pubmed/26395882 http://dx.doi.org/10.1186/s12882-015-0152-z |
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