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Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease

BACKGROUND: Chronic tissue damage induced by Helicobacter pylori (HP)-driven inflammation is considered the main risk of gastric carcinoma (GC). Epstein–Barr virus (EBV) infection has also been associated with GC. In this study, we aim to address the role of EBV in inflammatory GC precursor lesions...

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Autores principales: Cárdenas-Mondragón, M G, Torres, J, Flores-Luna, L, Camorlinga-Ponce, M, Carreón-Talavera, R, Gomez-Delgado, A, Kasamatsu, E, Fuentes-Pananá, E M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580389/
https://www.ncbi.nlm.nih.gov/pubmed/25996206
http://dx.doi.org/10.1038/bjc.2015.175
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author Cárdenas-Mondragón, M G
Torres, J
Flores-Luna, L
Camorlinga-Ponce, M
Carreón-Talavera, R
Gomez-Delgado, A
Kasamatsu, E
Fuentes-Pananá, E M
author_facet Cárdenas-Mondragón, M G
Torres, J
Flores-Luna, L
Camorlinga-Ponce, M
Carreón-Talavera, R
Gomez-Delgado, A
Kasamatsu, E
Fuentes-Pananá, E M
author_sort Cárdenas-Mondragón, M G
collection PubMed
description BACKGROUND: Chronic tissue damage induced by Helicobacter pylori (HP)-driven inflammation is considered the main risk of gastric carcinoma (GC). Epstein–Barr virus (EBV) infection has also been associated with GC. In this study, we aim to address the role of EBV in inflammatory GC precursor lesions and its added risk to HP infection. METHODS: Antibodies against EBV, HP and the bacterial virulence factor CagA were measured in sera from 525 Mexican and Paraguayan patients with gastric disease. Gastric samples were characterised according to the updated Sydney classification and associations were estimated between antibody responses and severity of both tissue damage and inflammation. RESULTS: We found significant associations (odd ratios and trends) between EBV and HP copositivity and premalignant lesions and intestinal-type GC. The EBV and HP coinfection was also significantly associated with increased infiltration of immune cells. No association was found between EBV and the less inflammation-driven diffuse-type GC. CONCLUSIONS: Our study suggests that EBV co-participates with HP to induce severe inflammation, increasing the risk of progression to intestinal-type GC.
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spelling pubmed-45803892016-06-09 Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease Cárdenas-Mondragón, M G Torres, J Flores-Luna, L Camorlinga-Ponce, M Carreón-Talavera, R Gomez-Delgado, A Kasamatsu, E Fuentes-Pananá, E M Br J Cancer Clinical Study BACKGROUND: Chronic tissue damage induced by Helicobacter pylori (HP)-driven inflammation is considered the main risk of gastric carcinoma (GC). Epstein–Barr virus (EBV) infection has also been associated with GC. In this study, we aim to address the role of EBV in inflammatory GC precursor lesions and its added risk to HP infection. METHODS: Antibodies against EBV, HP and the bacterial virulence factor CagA were measured in sera from 525 Mexican and Paraguayan patients with gastric disease. Gastric samples were characterised according to the updated Sydney classification and associations were estimated between antibody responses and severity of both tissue damage and inflammation. RESULTS: We found significant associations (odd ratios and trends) between EBV and HP copositivity and premalignant lesions and intestinal-type GC. The EBV and HP coinfection was also significantly associated with increased infiltration of immune cells. No association was found between EBV and the less inflammation-driven diffuse-type GC. CONCLUSIONS: Our study suggests that EBV co-participates with HP to induce severe inflammation, increasing the risk of progression to intestinal-type GC. Nature Publishing Group 2015-06-09 2015-05-21 /pmc/articles/PMC4580389/ /pubmed/25996206 http://dx.doi.org/10.1038/bjc.2015.175 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Clinical Study
Cárdenas-Mondragón, M G
Torres, J
Flores-Luna, L
Camorlinga-Ponce, M
Carreón-Talavera, R
Gomez-Delgado, A
Kasamatsu, E
Fuentes-Pananá, E M
Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease
title Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease
title_full Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease
title_fullStr Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease
title_full_unstemmed Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease
title_short Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease
title_sort case–control study of epstein–barr virus and helicobacter pylori serology in latin american patients with gastric disease
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580389/
https://www.ncbi.nlm.nih.gov/pubmed/25996206
http://dx.doi.org/10.1038/bjc.2015.175
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