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Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease

BACKGROUND AND OBJECTIVES: Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a multifunctional protein involved in the DNA base excision repair pathway, inflammation, angiogenesis, and survival pathways. We investigated serum APE1/Ref-1 in patients with coronary artery dis...

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Autores principales: Jin, Seon-Ah, Seo, Hee Jung, Kim, Sun Kyeong, Lee, Yu Ran, Choi, Sunga, Ahn, Kye-Taek, Kim, Jun-Hyung, Park, Jae-Hyeong, Lee, Jae-Hwan, Choi, Si Wan, Seong, In-Whan, Jeon, Byeong Hwa, Jeong, Jin-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Cardiology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580694/
https://www.ncbi.nlm.nih.gov/pubmed/26413103
http://dx.doi.org/10.4070/kcj.2015.45.5.364
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author Jin, Seon-Ah
Seo, Hee Jung
Kim, Sun Kyeong
Lee, Yu Ran
Choi, Sunga
Ahn, Kye-Taek
Kim, Jun-Hyung
Park, Jae-Hyeong
Lee, Jae-Hwan
Choi, Si Wan
Seong, In-Whan
Jeon, Byeong Hwa
Jeong, Jin-Ok
author_facet Jin, Seon-Ah
Seo, Hee Jung
Kim, Sun Kyeong
Lee, Yu Ran
Choi, Sunga
Ahn, Kye-Taek
Kim, Jun-Hyung
Park, Jae-Hyeong
Lee, Jae-Hwan
Choi, Si Wan
Seong, In-Whan
Jeon, Byeong Hwa
Jeong, Jin-Ok
author_sort Jin, Seon-Ah
collection PubMed
description BACKGROUND AND OBJECTIVES: Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a multifunctional protein involved in the DNA base excision repair pathway, inflammation, angiogenesis, and survival pathways. We investigated serum APE1/Ref-1 in patients with coronary artery disease (CAD). SUBJECTS AND METHODS: Serum APE1/Ref-1 was measured with a sandwich enzyme-linked immunosorbent assay from 360 patients who received coronary angiograms. They were divided into two groups; a control (n=57) and a CAD group (n=303), the latter included angina (n=128) and myocardial infarction (MI, n=175). RESULTS: The levels of APE1/Ref-1 were higher in the CAD than the control (0.63±0.07 vs. 0.12±0.07 ng/100 µL, respectively; p<0.01). They were also higher in MI than angina (0.81±0.10 vs. 0.38±0.11 ng/100 µL, respectively; p<0.01) and different according to the thrombolysis in myocardial infarction (TIMI) flow (0.88±0.09 for TIMI flow 0, 1, 2 vs. 0.45±0.13 ng/100 µL for TIMI flow 3, p<0.01) in acute coronary syndrome. In correlation analysis, the levels of APE1/Ref-1 were positively correlated with Troponin I (r=0.222; p<0.0001) and N-terminal pro-B type natriuretic peptide (NT-proBNP, r=0.217; p<0.0001) but not high sensitivity to C-reactive protein. Also, they revealed a negative correlation with ejection fraction (EF, r=-0.221; p=0.002). However, there were no significant differences among the three groups, were divided by their levels of APE1/Ref-1, for major adverse cardiovascular events (death, recurrent MI, stroke, revascularization) (8.2 vs. 14.0 vs. 12.5%, p=ns). CONCLUSION: The levels of serum APE1/Ref-1 are elevated in CAD, and are higher in MI than in angina. They are correlated with Troponin I, NT-proBNP, and EF.
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spelling pubmed-45806942015-09-25 Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease Jin, Seon-Ah Seo, Hee Jung Kim, Sun Kyeong Lee, Yu Ran Choi, Sunga Ahn, Kye-Taek Kim, Jun-Hyung Park, Jae-Hyeong Lee, Jae-Hwan Choi, Si Wan Seong, In-Whan Jeon, Byeong Hwa Jeong, Jin-Ok Korean Circ J Original Article BACKGROUND AND OBJECTIVES: Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a multifunctional protein involved in the DNA base excision repair pathway, inflammation, angiogenesis, and survival pathways. We investigated serum APE1/Ref-1 in patients with coronary artery disease (CAD). SUBJECTS AND METHODS: Serum APE1/Ref-1 was measured with a sandwich enzyme-linked immunosorbent assay from 360 patients who received coronary angiograms. They were divided into two groups; a control (n=57) and a CAD group (n=303), the latter included angina (n=128) and myocardial infarction (MI, n=175). RESULTS: The levels of APE1/Ref-1 were higher in the CAD than the control (0.63±0.07 vs. 0.12±0.07 ng/100 µL, respectively; p<0.01). They were also higher in MI than angina (0.81±0.10 vs. 0.38±0.11 ng/100 µL, respectively; p<0.01) and different according to the thrombolysis in myocardial infarction (TIMI) flow (0.88±0.09 for TIMI flow 0, 1, 2 vs. 0.45±0.13 ng/100 µL for TIMI flow 3, p<0.01) in acute coronary syndrome. In correlation analysis, the levels of APE1/Ref-1 were positively correlated with Troponin I (r=0.222; p<0.0001) and N-terminal pro-B type natriuretic peptide (NT-proBNP, r=0.217; p<0.0001) but not high sensitivity to C-reactive protein. Also, they revealed a negative correlation with ejection fraction (EF, r=-0.221; p=0.002). However, there were no significant differences among the three groups, were divided by their levels of APE1/Ref-1, for major adverse cardiovascular events (death, recurrent MI, stroke, revascularization) (8.2 vs. 14.0 vs. 12.5%, p=ns). CONCLUSION: The levels of serum APE1/Ref-1 are elevated in CAD, and are higher in MI than in angina. They are correlated with Troponin I, NT-proBNP, and EF. The Korean Society of Cardiology 2015-09 2015-04-22 /pmc/articles/PMC4580694/ /pubmed/26413103 http://dx.doi.org/10.4070/kcj.2015.45.5.364 Text en Copyright © 2015 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jin, Seon-Ah
Seo, Hee Jung
Kim, Sun Kyeong
Lee, Yu Ran
Choi, Sunga
Ahn, Kye-Taek
Kim, Jun-Hyung
Park, Jae-Hyeong
Lee, Jae-Hwan
Choi, Si Wan
Seong, In-Whan
Jeon, Byeong Hwa
Jeong, Jin-Ok
Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease
title Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease
title_full Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease
title_fullStr Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease
title_full_unstemmed Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease
title_short Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease
title_sort elevation of the serum apurinic/apyrimidinic endonuclease 1/redox factor-1 in coronary artery disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580694/
https://www.ncbi.nlm.nih.gov/pubmed/26413103
http://dx.doi.org/10.4070/kcj.2015.45.5.364
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