Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology

This study investigated the comparative accuracy of a recombinant 56-kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies by using conventional serology in well-characterized serum samples from undifferentiated febrile illness patients. The...

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Detalles Bibliográficos
Autores principales: Kingston, Hugh W. F., Blacksell, Stuart D., Tanganuchitcharnchai, Ampai, Laongnualpanich, Achara, Basnyat, Buddha, Day, Nicholas P. J., Paris, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Diagnostic Laboratory Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580738/
https://www.ncbi.nlm.nih.gov/pubmed/26291089
http://dx.doi.org/10.1128/CVI.00390-15
Descripción
Sumario:This study investigated the comparative accuracy of a recombinant 56-kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies by using conventional serology in well-characterized serum samples from undifferentiated febrile illness patients. The RDT showed high specificity and promising comparative accuracy, with 82% sensitivity and 98% specificity for samples defined positive at an IgM indirect immunofluorescence assay positivity cutoff titer of ≥1:1,600 versus 92% and 95% at ≥1:6,400, respectively.

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