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Roles of mTOR Signaling in Brain Development

mTOR is a serine/threonine kinase composed of multiple protein components. Intracellular signaling of mTOR complexes is involved in many of physiological functions including cell survival, proliferation and differentiation through the regulation of protein synthesis in multiple cell types. During br...

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Detalles Bibliográficos
Autor principal: Lee, Da Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580744/
https://www.ncbi.nlm.nih.gov/pubmed/26412966
http://dx.doi.org/10.5607/en.2015.24.3.177
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author Lee, Da Yong
author_facet Lee, Da Yong
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description mTOR is a serine/threonine kinase composed of multiple protein components. Intracellular signaling of mTOR complexes is involved in many of physiological functions including cell survival, proliferation and differentiation through the regulation of protein synthesis in multiple cell types. During brain development, mTOR-mediated signaling pathway plays a crucial role in the process of neuronal and glial differentiation and the maintenance of the stemness of neural stem cells. The abnormalities in the activity of mTOR and its downstream signaling molecules in neural stem cells result in severe defects of brain developmental processes causing a significant number of brain disorders, such as pediatric brain tumors, autism, seizure, learning disability and mental retardation. Understanding the implication of mTOR activity in neural stem cells would be able to provide an important clue in the development of future brain developmental disorder therapies.
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spelling pubmed-45807442015-09-25 Roles of mTOR Signaling in Brain Development Lee, Da Yong Exp Neurobiol Review Article mTOR is a serine/threonine kinase composed of multiple protein components. Intracellular signaling of mTOR complexes is involved in many of physiological functions including cell survival, proliferation and differentiation through the regulation of protein synthesis in multiple cell types. During brain development, mTOR-mediated signaling pathway plays a crucial role in the process of neuronal and glial differentiation and the maintenance of the stemness of neural stem cells. The abnormalities in the activity of mTOR and its downstream signaling molecules in neural stem cells result in severe defects of brain developmental processes causing a significant number of brain disorders, such as pediatric brain tumors, autism, seizure, learning disability and mental retardation. Understanding the implication of mTOR activity in neural stem cells would be able to provide an important clue in the development of future brain developmental disorder therapies. The Korean Society for Brain and Neural Science 2015-09 2015-09-17 /pmc/articles/PMC4580744/ /pubmed/26412966 http://dx.doi.org/10.5607/en.2015.24.3.177 Text en Copyright © Experimental Neurobiology 2015. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Da Yong
Roles of mTOR Signaling in Brain Development
title Roles of mTOR Signaling in Brain Development
title_full Roles of mTOR Signaling in Brain Development
title_fullStr Roles of mTOR Signaling in Brain Development
title_full_unstemmed Roles of mTOR Signaling in Brain Development
title_short Roles of mTOR Signaling in Brain Development
title_sort roles of mtor signaling in brain development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580744/
https://www.ncbi.nlm.nih.gov/pubmed/26412966
http://dx.doi.org/10.5607/en.2015.24.3.177
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