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International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation g...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580981/ https://www.ncbi.nlm.nih.gov/pubmed/26394269 http://dx.doi.org/10.1038/ncomms9019 |
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| author | Cordell, Heather J. Han, Younghun Mells, George F. Li, Yafang Hirschfield, Gideon M. Greene, Casey S. Xie, Gang Juran, Brian D. Zhu, Dakai Qian, David C. Floyd, James A. B. Morley, Katherine I. Prati, Daniele Lleo, Ana Cusi, Daniele Gershwin, M. Eric Anderson, Carl A. Lazaridis, Konstantinos N. Invernizzi, Pietro Seldin, Michael F. Sandford, Richard N. Amos, Christopher I. Siminovitch, Katherine A. |
| author_facet | Cordell, Heather J. Han, Younghun Mells, George F. Li, Yafang Hirschfield, Gideon M. Greene, Casey S. Xie, Gang Juran, Brian D. Zhu, Dakai Qian, David C. Floyd, James A. B. Morley, Katherine I. Prati, Daniele Lleo, Ana Cusi, Daniele Gershwin, M. Eric Anderson, Carl A. Lazaridis, Konstantinos N. Invernizzi, Pietro Seldin, Michael F. Sandford, Richard N. Amos, Christopher I. Siminovitch, Katherine A. |
| author_sort | Cordell, Heather J. |
| collection | PubMed |
| description | Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (P(combined)<5 × 10(−8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist. |
| format | Online Article Text |
| id | pubmed-4580981 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Nature Pub. Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-45809812015-10-21 International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways Cordell, Heather J. Han, Younghun Mells, George F. Li, Yafang Hirschfield, Gideon M. Greene, Casey S. Xie, Gang Juran, Brian D. Zhu, Dakai Qian, David C. Floyd, James A. B. Morley, Katherine I. Prati, Daniele Lleo, Ana Cusi, Daniele Gershwin, M. Eric Anderson, Carl A. Lazaridis, Konstantinos N. Invernizzi, Pietro Seldin, Michael F. Sandford, Richard N. Amos, Christopher I. Siminovitch, Katherine A. Nat Commun Article Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (P(combined)<5 × 10(−8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist. Nature Pub. Group 2015-09-22 /pmc/articles/PMC4580981/ /pubmed/26394269 http://dx.doi.org/10.1038/ncomms9019 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Cordell, Heather J. Han, Younghun Mells, George F. Li, Yafang Hirschfield, Gideon M. Greene, Casey S. Xie, Gang Juran, Brian D. Zhu, Dakai Qian, David C. Floyd, James A. B. Morley, Katherine I. Prati, Daniele Lleo, Ana Cusi, Daniele Gershwin, M. Eric Anderson, Carl A. Lazaridis, Konstantinos N. Invernizzi, Pietro Seldin, Michael F. Sandford, Richard N. Amos, Christopher I. Siminovitch, Katherine A. International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways |
| title | International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways |
| title_full | International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways |
| title_fullStr | International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways |
| title_full_unstemmed | International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways |
| title_short | International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways |
| title_sort | international genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580981/ https://www.ncbi.nlm.nih.gov/pubmed/26394269 http://dx.doi.org/10.1038/ncomms9019 |
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