Cargando…
Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer
Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associat...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580986/ https://www.ncbi.nlm.nih.gov/pubmed/26391404 http://dx.doi.org/10.1038/ncomms9234 |
| _version_ | 1782391485043310592 |
|---|---|
| author | Lawrenson, Kate Li, Qiyuan Kar, Siddhartha Seo, Ji-Heui Tyrer, Jonathan Spindler, Tassja J. Lee, Janet Chen, Yibu Karst, Alison Drapkin, Ronny Aben, Katja K. H. Anton-Culver, Hoda Antonenkova, Natalia Baker, Helen Bandera, Elisa V. Bean, Yukie Beckmann, Matthias W. Berchuck, Andrew Bisogna, Maria Bjorge, Line Bogdanova, Natalia Brinton, Louise A. Brooks-Wilson, Angela Bruinsma, Fiona Butzow, Ralf Campbell, Ian G. Carty, Karen Chang-Claude, Jenny Chenevix-Trench, Georgia Chen, Anne Chen, Zhihua Cook, Linda S. Cramer, Daniel W. Cunningham, Julie M. Cybulski, Cezary Dansonka-Mieszkowska, Agnieszka Dennis, Joe Dicks, Ed Doherty, Jennifer A. Dörk, Thilo du Bois, Andreas Dürst, Matthias Eccles, Diana Easton, Douglas T. Edwards, Robert P. Eilber, Ursula Ekici, Arif B. Fasching, Peter A. Fridley, Brooke L. Gao, Yu-Tang Gentry-Maharaj, Aleksandra Giles, Graham G. Glasspool, Rosalind Goode, Ellen L. Goodman, Marc T. Grownwald, Jacek Harrington, Patricia Harter, Philipp Hasmad, Hanis Nazihah Hein, Alexander Heitz, Florian Hildebrandt, Michelle A. T. Hillemanns, Peter Hogdall, Estrid Hogdall, Claus Hosono, Satoyo Iversen, Edwin S. Jakubowska, Anna James, Paul Jensen, Allan Ji, Bu-Tian Karlan, Beth Y. Kruger Kjaer, Susanne Kelemen, Linda E. Kellar, Melissa Kelley, Joseph L. Kiemeney, Lambertus A. Krakstad, Camilla Kupryjanczyk, Jolanta Lambrechts, Diether Lambrechts, Sandrina Le, Nhu D. Lee, Alice W. Lele, Shashi Leminen, Arto Lester, Jenny Levine, Douglas A. Liang, Dong Lissowska, Jolanta Lu, Karen Lubinski, Jan Lundvall, Lene Massuger, Leon F. A. G. Matsuo, Keitaro McGuire, Valerie McLaughlin, John R. Nevanlinna, Heli McNeish, Ian Menon, Usha Modugno, Francesmary Moysich, Kirsten B. Narod, Steven A. Nedergaard, Lotte Ness, Roberta B. Azmi, Mat Adenan Noor Odunsi, Kunle Olson, Sara H. Orlow, Irene Orsulic, Sandra Weber, Rachel Palmieri Pearce, Celeste L. Pejovic, Tanja Pelttari, Liisa M. Permuth-Wey, Jennifer Phelan, Catherine M. Pike, Malcolm C. Poole, Elizabeth M. Ramus, Susan J. Risch, Harvey A. Rosen, Barry Rossing, Mary Anne Rothstein, Joseph H. Rudolph, Anja Runnebaum, Ingo B. Rzepecka, Iwona K. Salvesen, Helga B. Schildkraut, Joellen M. Schwaab, Ira Sellers, Thomas A. Shu, Xiao-Ou Shvetsov, Yurii B. Siddiqui, Nadeem Sieh, Weiva Song, Honglin Southey, Melissa C. Sucheston, Lara Tangen, Ingvild L. Teo, Soo-Hwang Terry, Kathryn L. Thompson, Pamela J. Timorek, Agnieszka Tsai, Ya-Yu Tworoger, Shelley S. van Altena, Anne M. Van Nieuwenhuysen, Els Vergote, Ignace Vierkant, Robert A. Wang-Gohrke, Shan Walsh, Christine Wentzensen, Nicolas Whittemore, Alice S. Wicklund, Kristine G. Wilkens, Lynne R. Woo, Yin-Ling Wu, Xifeng Wu, Anna H. Yang, Hannah Zheng, Wei Ziogas, Argyrios Monteiro, Alvaro Pharoah, Paul D. Gayther, Simon A. Freedman, Matthew L. |
| author_facet | Lawrenson, Kate Li, Qiyuan Kar, Siddhartha Seo, Ji-Heui Tyrer, Jonathan Spindler, Tassja J. Lee, Janet Chen, Yibu Karst, Alison Drapkin, Ronny Aben, Katja K. H. Anton-Culver, Hoda Antonenkova, Natalia Baker, Helen Bandera, Elisa V. Bean, Yukie Beckmann, Matthias W. Berchuck, Andrew Bisogna, Maria Bjorge, Line Bogdanova, Natalia Brinton, Louise A. Brooks-Wilson, Angela Bruinsma, Fiona Butzow, Ralf Campbell, Ian G. Carty, Karen Chang-Claude, Jenny Chenevix-Trench, Georgia Chen, Anne Chen, Zhihua Cook, Linda S. Cramer, Daniel W. Cunningham, Julie M. Cybulski, Cezary Dansonka-Mieszkowska, Agnieszka Dennis, Joe Dicks, Ed Doherty, Jennifer A. Dörk, Thilo du Bois, Andreas Dürst, Matthias Eccles, Diana Easton, Douglas T. Edwards, Robert P. Eilber, Ursula Ekici, Arif B. Fasching, Peter A. Fridley, Brooke L. Gao, Yu-Tang Gentry-Maharaj, Aleksandra Giles, Graham G. Glasspool, Rosalind Goode, Ellen L. Goodman, Marc T. Grownwald, Jacek Harrington, Patricia Harter, Philipp Hasmad, Hanis Nazihah Hein, Alexander Heitz, Florian Hildebrandt, Michelle A. T. Hillemanns, Peter Hogdall, Estrid Hogdall, Claus Hosono, Satoyo Iversen, Edwin S. Jakubowska, Anna James, Paul Jensen, Allan Ji, Bu-Tian Karlan, Beth Y. Kruger Kjaer, Susanne Kelemen, Linda E. Kellar, Melissa Kelley, Joseph L. Kiemeney, Lambertus A. Krakstad, Camilla Kupryjanczyk, Jolanta Lambrechts, Diether Lambrechts, Sandrina Le, Nhu D. Lee, Alice W. Lele, Shashi Leminen, Arto Lester, Jenny Levine, Douglas A. Liang, Dong Lissowska, Jolanta Lu, Karen Lubinski, Jan Lundvall, Lene Massuger, Leon F. A. G. Matsuo, Keitaro McGuire, Valerie McLaughlin, John R. Nevanlinna, Heli McNeish, Ian Menon, Usha Modugno, Francesmary Moysich, Kirsten B. Narod, Steven A. Nedergaard, Lotte Ness, Roberta B. Azmi, Mat Adenan Noor Odunsi, Kunle Olson, Sara H. Orlow, Irene Orsulic, Sandra Weber, Rachel Palmieri Pearce, Celeste L. Pejovic, Tanja Pelttari, Liisa M. Permuth-Wey, Jennifer Phelan, Catherine M. Pike, Malcolm C. Poole, Elizabeth M. Ramus, Susan J. Risch, Harvey A. Rosen, Barry Rossing, Mary Anne Rothstein, Joseph H. Rudolph, Anja Runnebaum, Ingo B. Rzepecka, Iwona K. Salvesen, Helga B. Schildkraut, Joellen M. Schwaab, Ira Sellers, Thomas A. Shu, Xiao-Ou Shvetsov, Yurii B. Siddiqui, Nadeem Sieh, Weiva Song, Honglin Southey, Melissa C. Sucheston, Lara Tangen, Ingvild L. Teo, Soo-Hwang Terry, Kathryn L. Thompson, Pamela J. Timorek, Agnieszka Tsai, Ya-Yu Tworoger, Shelley S. van Altena, Anne M. Van Nieuwenhuysen, Els Vergote, Ignace Vierkant, Robert A. Wang-Gohrke, Shan Walsh, Christine Wentzensen, Nicolas Whittemore, Alice S. Wicklund, Kristine G. Wilkens, Lynne R. Woo, Yin-Ling Wu, Xifeng Wu, Anna H. Yang, Hannah Zheng, Wei Ziogas, Argyrios Monteiro, Alvaro Pharoah, Paul D. Gayther, Simon A. Freedman, Matthew L. |
| author_sort | Lawrenson, Kate |
| collection | PubMed |
| description | Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P≤10(−5)). For three cis-eQTL associations (P<1.4 × 10(−3), FDR<0.05) at 1p36 (CDC42), 1p34 (CDCA8) and 2q31 (HOXD9), we evaluate the functional role of each candidate by perturbing expression of each gene in HGSOC precursor cells. Overexpression of HOXD9 increases anchorage-independent growth, shortens population-doubling time and reduces contact inhibition. Chromosome conformation capture identifies an interaction between rs2857532 and the HOXD9 promoter, suggesting this SNP is a leading causal variant. Transcriptomic profiling after HOXD9 overexpression reveals enrichment of HGSOC risk variants within HOXD9 target genes (P=6 × 10(−10) for risk variants (P<10(−4)) within 10 kb of a HOXD9 target gene in ovarian cells), suggesting a broader role for this network in genetic susceptibility to HGSOC. |
| format | Online Article Text |
| id | pubmed-4580986 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Nature Pub. Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-45809862015-10-21 Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer Lawrenson, Kate Li, Qiyuan Kar, Siddhartha Seo, Ji-Heui Tyrer, Jonathan Spindler, Tassja J. Lee, Janet Chen, Yibu Karst, Alison Drapkin, Ronny Aben, Katja K. H. Anton-Culver, Hoda Antonenkova, Natalia Baker, Helen Bandera, Elisa V. Bean, Yukie Beckmann, Matthias W. Berchuck, Andrew Bisogna, Maria Bjorge, Line Bogdanova, Natalia Brinton, Louise A. Brooks-Wilson, Angela Bruinsma, Fiona Butzow, Ralf Campbell, Ian G. Carty, Karen Chang-Claude, Jenny Chenevix-Trench, Georgia Chen, Anne Chen, Zhihua Cook, Linda S. Cramer, Daniel W. Cunningham, Julie M. Cybulski, Cezary Dansonka-Mieszkowska, Agnieszka Dennis, Joe Dicks, Ed Doherty, Jennifer A. Dörk, Thilo du Bois, Andreas Dürst, Matthias Eccles, Diana Easton, Douglas T. Edwards, Robert P. Eilber, Ursula Ekici, Arif B. Fasching, Peter A. Fridley, Brooke L. Gao, Yu-Tang Gentry-Maharaj, Aleksandra Giles, Graham G. Glasspool, Rosalind Goode, Ellen L. Goodman, Marc T. Grownwald, Jacek Harrington, Patricia Harter, Philipp Hasmad, Hanis Nazihah Hein, Alexander Heitz, Florian Hildebrandt, Michelle A. T. Hillemanns, Peter Hogdall, Estrid Hogdall, Claus Hosono, Satoyo Iversen, Edwin S. Jakubowska, Anna James, Paul Jensen, Allan Ji, Bu-Tian Karlan, Beth Y. Kruger Kjaer, Susanne Kelemen, Linda E. Kellar, Melissa Kelley, Joseph L. Kiemeney, Lambertus A. Krakstad, Camilla Kupryjanczyk, Jolanta Lambrechts, Diether Lambrechts, Sandrina Le, Nhu D. Lee, Alice W. Lele, Shashi Leminen, Arto Lester, Jenny Levine, Douglas A. Liang, Dong Lissowska, Jolanta Lu, Karen Lubinski, Jan Lundvall, Lene Massuger, Leon F. A. G. Matsuo, Keitaro McGuire, Valerie McLaughlin, John R. Nevanlinna, Heli McNeish, Ian Menon, Usha Modugno, Francesmary Moysich, Kirsten B. Narod, Steven A. Nedergaard, Lotte Ness, Roberta B. Azmi, Mat Adenan Noor Odunsi, Kunle Olson, Sara H. Orlow, Irene Orsulic, Sandra Weber, Rachel Palmieri Pearce, Celeste L. Pejovic, Tanja Pelttari, Liisa M. Permuth-Wey, Jennifer Phelan, Catherine M. Pike, Malcolm C. Poole, Elizabeth M. Ramus, Susan J. Risch, Harvey A. Rosen, Barry Rossing, Mary Anne Rothstein, Joseph H. Rudolph, Anja Runnebaum, Ingo B. Rzepecka, Iwona K. Salvesen, Helga B. Schildkraut, Joellen M. Schwaab, Ira Sellers, Thomas A. Shu, Xiao-Ou Shvetsov, Yurii B. Siddiqui, Nadeem Sieh, Weiva Song, Honglin Southey, Melissa C. Sucheston, Lara Tangen, Ingvild L. Teo, Soo-Hwang Terry, Kathryn L. Thompson, Pamela J. Timorek, Agnieszka Tsai, Ya-Yu Tworoger, Shelley S. van Altena, Anne M. Van Nieuwenhuysen, Els Vergote, Ignace Vierkant, Robert A. Wang-Gohrke, Shan Walsh, Christine Wentzensen, Nicolas Whittemore, Alice S. Wicklund, Kristine G. Wilkens, Lynne R. Woo, Yin-Ling Wu, Xifeng Wu, Anna H. Yang, Hannah Zheng, Wei Ziogas, Argyrios Monteiro, Alvaro Pharoah, Paul D. Gayther, Simon A. Freedman, Matthew L. Nat Commun Article Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P≤10(−5)). For three cis-eQTL associations (P<1.4 × 10(−3), FDR<0.05) at 1p36 (CDC42), 1p34 (CDCA8) and 2q31 (HOXD9), we evaluate the functional role of each candidate by perturbing expression of each gene in HGSOC precursor cells. Overexpression of HOXD9 increases anchorage-independent growth, shortens population-doubling time and reduces contact inhibition. Chromosome conformation capture identifies an interaction between rs2857532 and the HOXD9 promoter, suggesting this SNP is a leading causal variant. Transcriptomic profiling after HOXD9 overexpression reveals enrichment of HGSOC risk variants within HOXD9 target genes (P=6 × 10(−10) for risk variants (P<10(−4)) within 10 kb of a HOXD9 target gene in ovarian cells), suggesting a broader role for this network in genetic susceptibility to HGSOC. Nature Pub. Group 2015-09-22 /pmc/articles/PMC4580986/ /pubmed/26391404 http://dx.doi.org/10.1038/ncomms9234 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Lawrenson, Kate Li, Qiyuan Kar, Siddhartha Seo, Ji-Heui Tyrer, Jonathan Spindler, Tassja J. Lee, Janet Chen, Yibu Karst, Alison Drapkin, Ronny Aben, Katja K. H. Anton-Culver, Hoda Antonenkova, Natalia Baker, Helen Bandera, Elisa V. Bean, Yukie Beckmann, Matthias W. Berchuck, Andrew Bisogna, Maria Bjorge, Line Bogdanova, Natalia Brinton, Louise A. Brooks-Wilson, Angela Bruinsma, Fiona Butzow, Ralf Campbell, Ian G. Carty, Karen Chang-Claude, Jenny Chenevix-Trench, Georgia Chen, Anne Chen, Zhihua Cook, Linda S. Cramer, Daniel W. Cunningham, Julie M. Cybulski, Cezary Dansonka-Mieszkowska, Agnieszka Dennis, Joe Dicks, Ed Doherty, Jennifer A. Dörk, Thilo du Bois, Andreas Dürst, Matthias Eccles, Diana Easton, Douglas T. Edwards, Robert P. Eilber, Ursula Ekici, Arif B. Fasching, Peter A. Fridley, Brooke L. Gao, Yu-Tang Gentry-Maharaj, Aleksandra Giles, Graham G. Glasspool, Rosalind Goode, Ellen L. Goodman, Marc T. Grownwald, Jacek Harrington, Patricia Harter, Philipp Hasmad, Hanis Nazihah Hein, Alexander Heitz, Florian Hildebrandt, Michelle A. T. Hillemanns, Peter Hogdall, Estrid Hogdall, Claus Hosono, Satoyo Iversen, Edwin S. Jakubowska, Anna James, Paul Jensen, Allan Ji, Bu-Tian Karlan, Beth Y. Kruger Kjaer, Susanne Kelemen, Linda E. Kellar, Melissa Kelley, Joseph L. Kiemeney, Lambertus A. Krakstad, Camilla Kupryjanczyk, Jolanta Lambrechts, Diether Lambrechts, Sandrina Le, Nhu D. Lee, Alice W. Lele, Shashi Leminen, Arto Lester, Jenny Levine, Douglas A. Liang, Dong Lissowska, Jolanta Lu, Karen Lubinski, Jan Lundvall, Lene Massuger, Leon F. A. G. Matsuo, Keitaro McGuire, Valerie McLaughlin, John R. Nevanlinna, Heli McNeish, Ian Menon, Usha Modugno, Francesmary Moysich, Kirsten B. Narod, Steven A. Nedergaard, Lotte Ness, Roberta B. Azmi, Mat Adenan Noor Odunsi, Kunle Olson, Sara H. Orlow, Irene Orsulic, Sandra Weber, Rachel Palmieri Pearce, Celeste L. Pejovic, Tanja Pelttari, Liisa M. Permuth-Wey, Jennifer Phelan, Catherine M. Pike, Malcolm C. Poole, Elizabeth M. Ramus, Susan J. Risch, Harvey A. Rosen, Barry Rossing, Mary Anne Rothstein, Joseph H. Rudolph, Anja Runnebaum, Ingo B. Rzepecka, Iwona K. Salvesen, Helga B. Schildkraut, Joellen M. Schwaab, Ira Sellers, Thomas A. Shu, Xiao-Ou Shvetsov, Yurii B. Siddiqui, Nadeem Sieh, Weiva Song, Honglin Southey, Melissa C. Sucheston, Lara Tangen, Ingvild L. Teo, Soo-Hwang Terry, Kathryn L. Thompson, Pamela J. Timorek, Agnieszka Tsai, Ya-Yu Tworoger, Shelley S. van Altena, Anne M. Van Nieuwenhuysen, Els Vergote, Ignace Vierkant, Robert A. Wang-Gohrke, Shan Walsh, Christine Wentzensen, Nicolas Whittemore, Alice S. Wicklund, Kristine G. Wilkens, Lynne R. Woo, Yin-Ling Wu, Xifeng Wu, Anna H. Yang, Hannah Zheng, Wei Ziogas, Argyrios Monteiro, Alvaro Pharoah, Paul D. Gayther, Simon A. Freedman, Matthew L. Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer |
| title | Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer |
| title_full | Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer |
| title_fullStr | Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer |
| title_full_unstemmed | Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer |
| title_short | Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer |
| title_sort | cis-eqtl analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580986/ https://www.ncbi.nlm.nih.gov/pubmed/26391404 http://dx.doi.org/10.1038/ncomms9234 |
| work_keys_str_mv | AT lawrensonkate ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT liqiyuan ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT karsiddhartha ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT seojiheui ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT tyrerjonathan ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT spindlertassjaj ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT leejanet ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT chenyibu ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT karstalison ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT drapkinronny ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT abenkatjakh ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT antonculverhoda ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT antonenkovanatalia ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT bakerhelen ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT banderaelisav ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT beanyukie ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT beckmannmatthiasw ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT berchuckandrew ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT bisognamaria ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT bjorgeline ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT bogdanovanatalia ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT brintonlouisea ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT brookswilsonangela ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT bruinsmafiona ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT butzowralf ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT campbelliang ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT cartykaren ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT changclaudejenny ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT chenevixtrenchgeorgia ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT chenanne ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT chenzhihua ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT cooklindas ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT cramerdanielw ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT cunninghamjuliem ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT cybulskicezary ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT dansonkamieszkowskaagnieszka ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT dennisjoe ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT dicksed ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT dohertyjennifera ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT dorkthilo ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT duboisandreas ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT durstmatthias ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT ecclesdiana ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT eastondouglast ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT edwardsrobertp ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT eilberursula ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT ekiciarifb ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT faschingpetera ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT fridleybrookel ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT gaoyutang ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT gentrymaharajaleksandra ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT gilesgrahamg ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT glasspoolrosalind ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT goodeellenl ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT goodmanmarct ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT grownwaldjacek ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT harringtonpatricia ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT harterphilipp ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT hasmadhanisnazihah ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT heinalexander ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT heitzflorian ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT hildebrandtmichelleat ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT hillemannspeter ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT hogdallestrid ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT hogdallclaus ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT hosonosatoyo ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT iversenedwins ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT jakubowskaanna ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT jamespaul ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT jensenallan ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT jibutian ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT karlanbethy ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT krugerkjaersusanne ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT kelemenlindae ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT kellarmelissa ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT kelleyjosephl ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT kiemeneylambertusa ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT krakstadcamilla ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT kupryjanczykjolanta ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT lambrechtsdiether ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT lambrechtssandrina ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT lenhud ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT leealicew ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT leleshashi ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT leminenarto ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT lesterjenny ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT levinedouglasa ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT liangdong ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT lissowskajolanta ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT lukaren ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT lubinskijan ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT lundvalllene ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT massugerleonfag ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT matsuokeitaro ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT mcguirevalerie ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT mclaughlinjohnr ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT nevanlinnaheli ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT mcneishian ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT menonusha ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT modugnofrancesmary ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT moysichkirstenb ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT narodstevena ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT nedergaardlotte ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT nessrobertab ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT azmimatadenannoor ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT odunsikunle ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT olsonsarah ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT orlowirene ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT orsulicsandra ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT weberrachelpalmieri ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT pearcecelestel ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT pejovictanja ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT pelttariliisam ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT permuthweyjennifer ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT phelancatherinem ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT pikemalcolmc ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT pooleelizabethm ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT ramussusanj ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT rischharveya ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT rosenbarry ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT rossingmaryanne ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT rothsteinjosephh ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT rudolphanja ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT runnebaumingob ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT rzepeckaiwonak ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT salvesenhelgab ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT schildkrautjoellenm ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT schwaabira ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT sellersthomasa ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT shuxiaoou ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT shvetsovyuriib ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT siddiquinadeem ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT siehweiva ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT songhonglin ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT southeymelissac ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT suchestonlara ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT tangeningvildl ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT teosoohwang ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT terrykathrynl ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT thompsonpamelaj ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT timorekagnieszka ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT tsaiyayu ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT tworogershelleys ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT vanaltenaannem ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT vannieuwenhuysenels ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT vergoteignace ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT vierkantroberta ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT wanggohrkeshan ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT walshchristine ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT wentzensennicolas ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT whittemorealices ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT wicklundkristineg ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT wilkenslynner ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT wooyinling ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT wuxifeng ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT wuannah ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT yanghannah ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT zhengwei ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT ziogasargyrios ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT monteiroalvaro ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT pharoahpauld ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT gaythersimona ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer AT freedmanmatthewl ciseqtlanalysisandfunctionalvalidationofcandidatesusceptibilitygenesforhighgradeserousovariancancer |