Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles

In 2010 a new Lagovirus related to rabbit haemorrhagic disease virus (RHDV) emerged in France and has since rapidly spread throughout domestic and wild rabbit populations of several European countries. The new virus, termed RHDV2, exhibits distinctive genetic, antigenic and pathogenic features. Nota...

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Autores principales: Bárcena, Juan, Guerra, Beatriz, Angulo, Iván, González, Julia, Valcárcel, Félix, Mata, Carlos P., Castón, José R., Blanco, Esther, Alejo, Alí
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581117/
https://www.ncbi.nlm.nih.gov/pubmed/26403184
http://dx.doi.org/10.1186/s13567-015-0245-5
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author Bárcena, Juan
Guerra, Beatriz
Angulo, Iván
González, Julia
Valcárcel, Félix
Mata, Carlos P.
Castón, José R.
Blanco, Esther
Alejo, Alí
author_facet Bárcena, Juan
Guerra, Beatriz
Angulo, Iván
González, Julia
Valcárcel, Félix
Mata, Carlos P.
Castón, José R.
Blanco, Esther
Alejo, Alí
author_sort Bárcena, Juan
collection PubMed
description In 2010 a new Lagovirus related to rabbit haemorrhagic disease virus (RHDV) emerged in France and has since rapidly spread throughout domestic and wild rabbit populations of several European countries. The new virus, termed RHDV2, exhibits distinctive genetic, antigenic and pathogenic features. Notably, RHDV2 kills rabbits previously vaccinated with RHDV vaccines. Here we report for the first time the generation and characterization of RHDV2-specific virus-like particles (VLPs). Our results further confirmed the differential antigenic properties exhibited by RHDV and RHDV2, highlighting the need of using RHDV2-specific diagnostic assays to monitor the spread of this new virus.
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spelling pubmed-45811172015-09-25 Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles Bárcena, Juan Guerra, Beatriz Angulo, Iván González, Julia Valcárcel, Félix Mata, Carlos P. Castón, José R. Blanco, Esther Alejo, Alí Vet Res Short Report In 2010 a new Lagovirus related to rabbit haemorrhagic disease virus (RHDV) emerged in France and has since rapidly spread throughout domestic and wild rabbit populations of several European countries. The new virus, termed RHDV2, exhibits distinctive genetic, antigenic and pathogenic features. Notably, RHDV2 kills rabbits previously vaccinated with RHDV vaccines. Here we report for the first time the generation and characterization of RHDV2-specific virus-like particles (VLPs). Our results further confirmed the differential antigenic properties exhibited by RHDV and RHDV2, highlighting the need of using RHDV2-specific diagnostic assays to monitor the spread of this new virus. BioMed Central 2015-09-24 2015 /pmc/articles/PMC4581117/ /pubmed/26403184 http://dx.doi.org/10.1186/s13567-015-0245-5 Text en © Bárcena et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Bárcena, Juan
Guerra, Beatriz
Angulo, Iván
González, Julia
Valcárcel, Félix
Mata, Carlos P.
Castón, José R.
Blanco, Esther
Alejo, Alí
Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles
title Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles
title_full Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles
title_fullStr Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles
title_full_unstemmed Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles
title_short Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles
title_sort comparative analysis of rabbit hemorrhagic disease virus (rhdv) and new rhdv2 virus antigenicity, using specific virus-like particles
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581117/
https://www.ncbi.nlm.nih.gov/pubmed/26403184
http://dx.doi.org/10.1186/s13567-015-0245-5
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