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New biomarkers for primary mitral regurgitation

BACKGROUND: Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered as a passive ongoing pathophysiological process and little is known about its physiological der...

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Autores principales: Deroyer, Céline, Magne, Julien, Moonen, Marie, Le Goff, Caroline, Dupont, Laura, Hulin, Alexia, Radermecker, Marc, Colige, Alain, Cavalier, Etienne, Kolh, Philippe, Pierard, Luc, Lancellotti, Patrizio, Merville, Marie-Paule, Fillet, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581160/
https://www.ncbi.nlm.nih.gov/pubmed/26405438
http://dx.doi.org/10.1186/s12014-015-9097-2
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author Deroyer, Céline
Magne, Julien
Moonen, Marie
Le Goff, Caroline
Dupont, Laura
Hulin, Alexia
Radermecker, Marc
Colige, Alain
Cavalier, Etienne
Kolh, Philippe
Pierard, Luc
Lancellotti, Patrizio
Merville, Marie-Paule
Fillet, Marianne
author_facet Deroyer, Céline
Magne, Julien
Moonen, Marie
Le Goff, Caroline
Dupont, Laura
Hulin, Alexia
Radermecker, Marc
Colige, Alain
Cavalier, Etienne
Kolh, Philippe
Pierard, Luc
Lancellotti, Patrizio
Merville, Marie-Paule
Fillet, Marianne
author_sort Deroyer, Céline
collection PubMed
description BACKGROUND: Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered as a passive ongoing pathophysiological process and little is known about its physiological deregulation. The purpose of this study was to highlight new biomarkers of mitral regurgitation in order to decipher the underlying pathological mechanism as well as to allow the diagnosis and the monitoring of the disease. RESULTS: Modulation of various blood proteins expression was examined in patients suffering from different grades of mitral regurgitation (mild, moderate and severe) compared to healthy controls. To this end, several routine clinical assays and the multi analyte profile technology targeting 184 proteins were used. High-density lipoprotein, apolipoprotein-A1, haptoglobin and haptoglobin-α2 chain levels significantly decreased proportionally to the degree of mitral regurgitation when compared to controls. High-density lipoprotein and apolipoprotein-A1 levels were associated with effective regurgitant orifice area and regurgitant volume. Apolipoprotein-A1 was an independent predictor of severe mitral regurgitation. Moreover, with ordinal logistic regression, apolipoprotein-A1 remained the only independent factor associated with mitral regurgitation. In addition, myxomatous mitral valves were studied by immunocytochemistry. We observed an increase of LC3, the marker of autophagy, in myxomatous mitral valves compared with healthy mitral valves. CONCLUSION: These potential biomarkers of mitral regurgitation highlighted different cellular processes that could be modified in myxomatous degenerescence: reverse cholesterol transport, antioxidant properties and autophagy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12014-015-9097-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-45811602015-09-25 New biomarkers for primary mitral regurgitation Deroyer, Céline Magne, Julien Moonen, Marie Le Goff, Caroline Dupont, Laura Hulin, Alexia Radermecker, Marc Colige, Alain Cavalier, Etienne Kolh, Philippe Pierard, Luc Lancellotti, Patrizio Merville, Marie-Paule Fillet, Marianne Clin Proteomics Research BACKGROUND: Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered as a passive ongoing pathophysiological process and little is known about its physiological deregulation. The purpose of this study was to highlight new biomarkers of mitral regurgitation in order to decipher the underlying pathological mechanism as well as to allow the diagnosis and the monitoring of the disease. RESULTS: Modulation of various blood proteins expression was examined in patients suffering from different grades of mitral regurgitation (mild, moderate and severe) compared to healthy controls. To this end, several routine clinical assays and the multi analyte profile technology targeting 184 proteins were used. High-density lipoprotein, apolipoprotein-A1, haptoglobin and haptoglobin-α2 chain levels significantly decreased proportionally to the degree of mitral regurgitation when compared to controls. High-density lipoprotein and apolipoprotein-A1 levels were associated with effective regurgitant orifice area and regurgitant volume. Apolipoprotein-A1 was an independent predictor of severe mitral regurgitation. Moreover, with ordinal logistic regression, apolipoprotein-A1 remained the only independent factor associated with mitral regurgitation. In addition, myxomatous mitral valves were studied by immunocytochemistry. We observed an increase of LC3, the marker of autophagy, in myxomatous mitral valves compared with healthy mitral valves. CONCLUSION: These potential biomarkers of mitral regurgitation highlighted different cellular processes that could be modified in myxomatous degenerescence: reverse cholesterol transport, antioxidant properties and autophagy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12014-015-9097-2) contains supplementary material, which is available to authorized users. BioMed Central 2015-09-24 /pmc/articles/PMC4581160/ /pubmed/26405438 http://dx.doi.org/10.1186/s12014-015-9097-2 Text en © Deroyer et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Deroyer, Céline
Magne, Julien
Moonen, Marie
Le Goff, Caroline
Dupont, Laura
Hulin, Alexia
Radermecker, Marc
Colige, Alain
Cavalier, Etienne
Kolh, Philippe
Pierard, Luc
Lancellotti, Patrizio
Merville, Marie-Paule
Fillet, Marianne
New biomarkers for primary mitral regurgitation
title New biomarkers for primary mitral regurgitation
title_full New biomarkers for primary mitral regurgitation
title_fullStr New biomarkers for primary mitral regurgitation
title_full_unstemmed New biomarkers for primary mitral regurgitation
title_short New biomarkers for primary mitral regurgitation
title_sort new biomarkers for primary mitral regurgitation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581160/
https://www.ncbi.nlm.nih.gov/pubmed/26405438
http://dx.doi.org/10.1186/s12014-015-9097-2
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