The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer

The role of microRNAs (miRNAs or miRs) in the pathology of epithelial ovarian cancer (EOC) has been extensively studied. Many miRNAs differentially expressed in EOC as compared to normal controls have been identified, prompting further inquiry into their role in the disease. miRNAs belonging to the...

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Detalles Bibliográficos
Autores principales: Muralidhar, Goda G., Barbolina, Maria V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581173/
https://www.ncbi.nlm.nih.gov/pubmed/26213923
http://dx.doi.org/10.3390/ijms160816833
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author Muralidhar, Goda G.
Barbolina, Maria V.
author_facet Muralidhar, Goda G.
Barbolina, Maria V.
author_sort Muralidhar, Goda G.
collection PubMed
description The role of microRNAs (miRNAs or miRs) in the pathology of epithelial ovarian cancer (EOC) has been extensively studied. Many miRNAs differentially expressed in EOC as compared to normal controls have been identified, prompting further inquiry into their role in the disease. miRNAs belonging to the miR-200 family have repeatedly surfaced over multiple profiling studies. In this review, we attempt to consolidate the data from different studies and highlight mechanisms by which these miRNAs influence progression of metastasis and chemo-resistance in EOC.
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spelling pubmed-45811732015-09-28 The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer Muralidhar, Goda G. Barbolina, Maria V. Int J Mol Sci Review The role of microRNAs (miRNAs or miRs) in the pathology of epithelial ovarian cancer (EOC) has been extensively studied. Many miRNAs differentially expressed in EOC as compared to normal controls have been identified, prompting further inquiry into their role in the disease. miRNAs belonging to the miR-200 family have repeatedly surfaced over multiple profiling studies. In this review, we attempt to consolidate the data from different studies and highlight mechanisms by which these miRNAs influence progression of metastasis and chemo-resistance in EOC. MDPI 2015-07-24 /pmc/articles/PMC4581173/ /pubmed/26213923 http://dx.doi.org/10.3390/ijms160816833 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Muralidhar, Goda G.
Barbolina, Maria V.
The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer
title The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer
title_full The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer
title_fullStr The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer
title_full_unstemmed The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer
title_short The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer
title_sort mir-200 family: versatile players in epithelial ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581173/
https://www.ncbi.nlm.nih.gov/pubmed/26213923
http://dx.doi.org/10.3390/ijms160816833
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