Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives

In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentratio...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Dongdong, Zhang, Wuxia, Wang, Tingting, Li, Na, Mu, Haibo, Zhang, Jiwen, Duan, Jinyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581214/
https://www.ncbi.nlm.nih.gov/pubmed/26263982
http://dx.doi.org/10.3390/ijms160817668
_version_ 1782391519740690432
author Wang, Dongdong
Zhang, Wuxia
Wang, Tingting
Li, Na
Mu, Haibo
Zhang, Jiwen
Duan, Jinyou
author_facet Wang, Dongdong
Zhang, Wuxia
Wang, Tingting
Li, Na
Mu, Haibo
Zhang, Jiwen
Duan, Jinyou
author_sort Wang, Dongdong
collection PubMed
description In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tanshinones might be potential candidates as antibacterial agents.
format Online
Article
Text
id pubmed-4581214
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-45812142015-09-28 Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives Wang, Dongdong Zhang, Wuxia Wang, Tingting Li, Na Mu, Haibo Zhang, Jiwen Duan, Jinyou Int J Mol Sci Article In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tanshinones might be potential candidates as antibacterial agents. MDPI 2015-07-31 /pmc/articles/PMC4581214/ /pubmed/26263982 http://dx.doi.org/10.3390/ijms160817668 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Dongdong
Zhang, Wuxia
Wang, Tingting
Li, Na
Mu, Haibo
Zhang, Jiwen
Duan, Jinyou
Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives
title Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives
title_full Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives
title_fullStr Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives
title_full_unstemmed Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives
title_short Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives
title_sort unveiling the mode of action of two antibacterial tanshinone derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581214/
https://www.ncbi.nlm.nih.gov/pubmed/26263982
http://dx.doi.org/10.3390/ijms160817668
work_keys_str_mv AT wangdongdong unveilingthemodeofactionoftwoantibacterialtanshinonederivatives
AT zhangwuxia unveilingthemodeofactionoftwoantibacterialtanshinonederivatives
AT wangtingting unveilingthemodeofactionoftwoantibacterialtanshinonederivatives
AT lina unveilingthemodeofactionoftwoantibacterialtanshinonederivatives
AT muhaibo unveilingthemodeofactionoftwoantibacterialtanshinonederivatives
AT zhangjiwen unveilingthemodeofactionoftwoantibacterialtanshinonederivatives
AT duanjinyou unveilingthemodeofactionoftwoantibacterialtanshinonederivatives

Ejemplares similares