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Hepatitis B Virus Infection, MicroRNAs and Liver Disease

Hepatitis B virus (HBV) attacks the liver and can cause both acute as well as chronic liver diseases which might lead to liver cirrhosis and hepatocellular carcinoma. Regardless of the availability of a vaccine and numerous treatment options, HBV is a major cause of morbidity and mortality across th...

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Detalles Bibliográficos
Autores principales: Sarkar, Neelakshi, Chakravarty, Runu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581219/
https://www.ncbi.nlm.nih.gov/pubmed/26247932
http://dx.doi.org/10.3390/ijms160817746
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author Sarkar, Neelakshi
Chakravarty, Runu
author_facet Sarkar, Neelakshi
Chakravarty, Runu
author_sort Sarkar, Neelakshi
collection PubMed
description Hepatitis B virus (HBV) attacks the liver and can cause both acute as well as chronic liver diseases which might lead to liver cirrhosis and hepatocellular carcinoma. Regardless of the availability of a vaccine and numerous treatment options, HBV is a major cause of morbidity and mortality across the world. Recently, microRNAs (miRNAs) have emerged as important modulators of gene function. Studies on the role of miRNA in the regulation of hepatitis B virus gene expression have been the focus of modern antiviral research. miRNAs can regulate viral replication and pathogenesis in a number of different ways, which includefacilitation, direct or indirect inhibition, activation of immune response, epigenetic modulation, etc. Nevertheless, these mechanisms can appropriately be used with a diagnosticand/or therapeutic approach. The present review is an attempt to classify specific miRNAs that are reported to be associated with various aspects of hepatitis B biology, in order to precisely present the participation of individual miRNAs in multiple aspects relating to HBV.
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spelling pubmed-45812192015-09-28 Hepatitis B Virus Infection, MicroRNAs and Liver Disease Sarkar, Neelakshi Chakravarty, Runu Int J Mol Sci Review Hepatitis B virus (HBV) attacks the liver and can cause both acute as well as chronic liver diseases which might lead to liver cirrhosis and hepatocellular carcinoma. Regardless of the availability of a vaccine and numerous treatment options, HBV is a major cause of morbidity and mortality across the world. Recently, microRNAs (miRNAs) have emerged as important modulators of gene function. Studies on the role of miRNA in the regulation of hepatitis B virus gene expression have been the focus of modern antiviral research. miRNAs can regulate viral replication and pathogenesis in a number of different ways, which includefacilitation, direct or indirect inhibition, activation of immune response, epigenetic modulation, etc. Nevertheless, these mechanisms can appropriately be used with a diagnosticand/or therapeutic approach. The present review is an attempt to classify specific miRNAs that are reported to be associated with various aspects of hepatitis B biology, in order to precisely present the participation of individual miRNAs in multiple aspects relating to HBV. MDPI 2015-08-03 /pmc/articles/PMC4581219/ /pubmed/26247932 http://dx.doi.org/10.3390/ijms160817746 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sarkar, Neelakshi
Chakravarty, Runu
Hepatitis B Virus Infection, MicroRNAs and Liver Disease
title Hepatitis B Virus Infection, MicroRNAs and Liver Disease
title_full Hepatitis B Virus Infection, MicroRNAs and Liver Disease
title_fullStr Hepatitis B Virus Infection, MicroRNAs and Liver Disease
title_full_unstemmed Hepatitis B Virus Infection, MicroRNAs and Liver Disease
title_short Hepatitis B Virus Infection, MicroRNAs and Liver Disease
title_sort hepatitis b virus infection, micrornas and liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581219/
https://www.ncbi.nlm.nih.gov/pubmed/26247932
http://dx.doi.org/10.3390/ijms160817746
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