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Hepatitis B Virus Infection, MicroRNAs and Liver Disease
Hepatitis B virus (HBV) attacks the liver and can cause both acute as well as chronic liver diseases which might lead to liver cirrhosis and hepatocellular carcinoma. Regardless of the availability of a vaccine and numerous treatment options, HBV is a major cause of morbidity and mortality across th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581219/ https://www.ncbi.nlm.nih.gov/pubmed/26247932 http://dx.doi.org/10.3390/ijms160817746 |
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author | Sarkar, Neelakshi Chakravarty, Runu |
author_facet | Sarkar, Neelakshi Chakravarty, Runu |
author_sort | Sarkar, Neelakshi |
collection | PubMed |
description | Hepatitis B virus (HBV) attacks the liver and can cause both acute as well as chronic liver diseases which might lead to liver cirrhosis and hepatocellular carcinoma. Regardless of the availability of a vaccine and numerous treatment options, HBV is a major cause of morbidity and mortality across the world. Recently, microRNAs (miRNAs) have emerged as important modulators of gene function. Studies on the role of miRNA in the regulation of hepatitis B virus gene expression have been the focus of modern antiviral research. miRNAs can regulate viral replication and pathogenesis in a number of different ways, which includefacilitation, direct or indirect inhibition, activation of immune response, epigenetic modulation, etc. Nevertheless, these mechanisms can appropriately be used with a diagnosticand/or therapeutic approach. The present review is an attempt to classify specific miRNAs that are reported to be associated with various aspects of hepatitis B biology, in order to precisely present the participation of individual miRNAs in multiple aspects relating to HBV. |
format | Online Article Text |
id | pubmed-4581219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45812192015-09-28 Hepatitis B Virus Infection, MicroRNAs and Liver Disease Sarkar, Neelakshi Chakravarty, Runu Int J Mol Sci Review Hepatitis B virus (HBV) attacks the liver and can cause both acute as well as chronic liver diseases which might lead to liver cirrhosis and hepatocellular carcinoma. Regardless of the availability of a vaccine and numerous treatment options, HBV is a major cause of morbidity and mortality across the world. Recently, microRNAs (miRNAs) have emerged as important modulators of gene function. Studies on the role of miRNA in the regulation of hepatitis B virus gene expression have been the focus of modern antiviral research. miRNAs can regulate viral replication and pathogenesis in a number of different ways, which includefacilitation, direct or indirect inhibition, activation of immune response, epigenetic modulation, etc. Nevertheless, these mechanisms can appropriately be used with a diagnosticand/or therapeutic approach. The present review is an attempt to classify specific miRNAs that are reported to be associated with various aspects of hepatitis B biology, in order to precisely present the participation of individual miRNAs in multiple aspects relating to HBV. MDPI 2015-08-03 /pmc/articles/PMC4581219/ /pubmed/26247932 http://dx.doi.org/10.3390/ijms160817746 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sarkar, Neelakshi Chakravarty, Runu Hepatitis B Virus Infection, MicroRNAs and Liver Disease |
title | Hepatitis B Virus Infection, MicroRNAs and Liver Disease |
title_full | Hepatitis B Virus Infection, MicroRNAs and Liver Disease |
title_fullStr | Hepatitis B Virus Infection, MicroRNAs and Liver Disease |
title_full_unstemmed | Hepatitis B Virus Infection, MicroRNAs and Liver Disease |
title_short | Hepatitis B Virus Infection, MicroRNAs and Liver Disease |
title_sort | hepatitis b virus infection, micrornas and liver disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581219/ https://www.ncbi.nlm.nih.gov/pubmed/26247932 http://dx.doi.org/10.3390/ijms160817746 |
work_keys_str_mv | AT sarkarneelakshi hepatitisbvirusinfectionmicrornasandliverdisease AT chakravartyrunu hepatitisbvirusinfectionmicrornasandliverdisease |