Membrane Affinity of Platensimycin and Its Dialkylamine Analogs

Membrane permeability is a desired property in drug design, but there have been difficulties in quantifying the direct drug partitioning into native membranes. Platensimycin (PL) is a new promising antibiotic whose biosynthetic production is costly. Six dialkylamine analogs of PL were synthesized wi...

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Detalles Bibliográficos
Autores principales: Rowe, Ian, Guo, Min, Yasmann, Anthony, Cember, Abigail, Sintim, Herman O., Sukharev, Sergei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581228/
https://www.ncbi.nlm.nih.gov/pubmed/26247942
http://dx.doi.org/10.3390/ijms160817909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581228/
https://www.ncbi.nlm.nih.gov/pubmed/26247942
http://dx.doi.org/10.3390/ijms160817909

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