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Membrane Affinity of Platensimycin and Its Dialkylamine Analogs
Membrane permeability is a desired property in drug design, but there have been difficulties in quantifying the direct drug partitioning into native membranes. Platensimycin (PL) is a new promising antibiotic whose biosynthetic production is costly. Six dialkylamine analogs of PL were synthesized wi...
Autores principales: | Rowe, Ian, Guo, Min, Yasmann, Anthony, Cember, Abigail, Sintim, Herman O., Sukharev, Sergei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581228/ https://www.ncbi.nlm.nih.gov/pubmed/26247942 http://dx.doi.org/10.3390/ijms160817909 |
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