Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells

The generation of induced pluripotent stem cells (iPSCs) has opened up a new scientific frontier in medicine. This technology has made it possible to obtain pluripotent stem cells from individuals with genetic disorders. Because iPSCs carry the identical genetic anomalies related to those disorders,...

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Detalles Bibliográficos
Autores principales: Tanaka, Atsushi, Yuasa, Shinsuke, Node, Koichi, Fukuda, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581278/
https://www.ncbi.nlm.nih.gov/pubmed/26274955
http://dx.doi.org/10.3390/ijms160818894
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author Tanaka, Atsushi
Yuasa, Shinsuke
Node, Koichi
Fukuda, Keiichi
author_facet Tanaka, Atsushi
Yuasa, Shinsuke
Node, Koichi
Fukuda, Keiichi
author_sort Tanaka, Atsushi
collection PubMed
description The generation of induced pluripotent stem cells (iPSCs) has opened up a new scientific frontier in medicine. This technology has made it possible to obtain pluripotent stem cells from individuals with genetic disorders. Because iPSCs carry the identical genetic anomalies related to those disorders, iPSCs are an ideal platform for medical research. The pathophysiological cellular phenotypes of genetically heritable heart diseases such as arrhythmias and cardiomyopathies, have been modeled on cell culture dishes using disease-specific iPSC-derived cardiomyocytes. These model systems can potentially provide new insights into disease mechanisms and drug discoveries. This review focuses on recent progress in cardiovascular disease modeling using iPSCs, and discusses problems and future perspectives concerning their use.
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spelling pubmed-45812782015-09-28 Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells Tanaka, Atsushi Yuasa, Shinsuke Node, Koichi Fukuda, Keiichi Int J Mol Sci Review The generation of induced pluripotent stem cells (iPSCs) has opened up a new scientific frontier in medicine. This technology has made it possible to obtain pluripotent stem cells from individuals with genetic disorders. Because iPSCs carry the identical genetic anomalies related to those disorders, iPSCs are an ideal platform for medical research. The pathophysiological cellular phenotypes of genetically heritable heart diseases such as arrhythmias and cardiomyopathies, have been modeled on cell culture dishes using disease-specific iPSC-derived cardiomyocytes. These model systems can potentially provide new insights into disease mechanisms and drug discoveries. This review focuses on recent progress in cardiovascular disease modeling using iPSCs, and discusses problems and future perspectives concerning their use. MDPI 2015-08-12 /pmc/articles/PMC4581278/ /pubmed/26274955 http://dx.doi.org/10.3390/ijms160818894 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tanaka, Atsushi
Yuasa, Shinsuke
Node, Koichi
Fukuda, Keiichi
Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells
title Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells
title_full Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells
title_fullStr Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells
title_full_unstemmed Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells
title_short Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells
title_sort cardiovascular disease modeling using patient-specific induced pluripotent stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581278/
https://www.ncbi.nlm.nih.gov/pubmed/26274955
http://dx.doi.org/10.3390/ijms160818894
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