Terpenoids from the Octocoral Sinularia gaweli

Two eudesmane sesquiterpenoids, verticillatol (1) and 5α-acetoxy-4(14)-eudesmene-1β-ol (2) and two cembrane diterpenoids, (–)-leptodiol acetate (3) and sinulacembranolide A (4) were isolated from the octocoral Sinularia gaweli and compounds 2–4 are new isolates. The structures of new terpenoids 2–4...

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Autores principales: Lin, Wun-Jie, Wu, Tung-Ying, Su, Tzu-Rong, Wen, Zhi-Hong, Chen, Jih-Jung, Fang, Lee-Shing, Wu, Yang-Chang, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581310/
https://www.ncbi.nlm.nih.gov/pubmed/26295226
http://dx.doi.org/10.3390/ijms160819508
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author Lin, Wun-Jie
Wu, Tung-Ying
Su, Tzu-Rong
Wen, Zhi-Hong
Chen, Jih-Jung
Fang, Lee-Shing
Wu, Yang-Chang
Sung, Ping-Jyun
author_facet Lin, Wun-Jie
Wu, Tung-Ying
Su, Tzu-Rong
Wen, Zhi-Hong
Chen, Jih-Jung
Fang, Lee-Shing
Wu, Yang-Chang
Sung, Ping-Jyun
author_sort Lin, Wun-Jie
collection PubMed
description Two eudesmane sesquiterpenoids, verticillatol (1) and 5α-acetoxy-4(14)-eudesmene-1β-ol (2) and two cembrane diterpenoids, (–)-leptodiol acetate (3) and sinulacembranolide A (4) were isolated from the octocoral Sinularia gaweli and compounds 2–4 are new isolates. The structures of new terpenoids 2–4 were elucidated by spectroscopic methods and by comparison the spectral data with those of known analogues. Terpenoid 4 was found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 marcophage cells.
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spelling pubmed-45813102015-09-28 Terpenoids from the Octocoral Sinularia gaweli Lin, Wun-Jie Wu, Tung-Ying Su, Tzu-Rong Wen, Zhi-Hong Chen, Jih-Jung Fang, Lee-Shing Wu, Yang-Chang Sung, Ping-Jyun Int J Mol Sci Article Two eudesmane sesquiterpenoids, verticillatol (1) and 5α-acetoxy-4(14)-eudesmene-1β-ol (2) and two cembrane diterpenoids, (–)-leptodiol acetate (3) and sinulacembranolide A (4) were isolated from the octocoral Sinularia gaweli and compounds 2–4 are new isolates. The structures of new terpenoids 2–4 were elucidated by spectroscopic methods and by comparison the spectral data with those of known analogues. Terpenoid 4 was found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 marcophage cells. MDPI 2015-08-18 /pmc/articles/PMC4581310/ /pubmed/26295226 http://dx.doi.org/10.3390/ijms160819508 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Wun-Jie
Wu, Tung-Ying
Su, Tzu-Rong
Wen, Zhi-Hong
Chen, Jih-Jung
Fang, Lee-Shing
Wu, Yang-Chang
Sung, Ping-Jyun
Terpenoids from the Octocoral Sinularia gaweli
title Terpenoids from the Octocoral Sinularia gaweli
title_full Terpenoids from the Octocoral Sinularia gaweli
title_fullStr Terpenoids from the Octocoral Sinularia gaweli
title_full_unstemmed Terpenoids from the Octocoral Sinularia gaweli
title_short Terpenoids from the Octocoral Sinularia gaweli
title_sort terpenoids from the octocoral sinularia gaweli
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581310/
https://www.ncbi.nlm.nih.gov/pubmed/26295226
http://dx.doi.org/10.3390/ijms160819508
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