Possibility of lanthanum absorption in the stomach

Lanthanum carbonate (LC) is an orally administered phosphate binder. Its absorption is generally thought to be minimal. We report here the case of an 81-year-old woman who underwent subtotal gastrectomy for gastric cancer after receiving hemodialysis for 1 year and taking LC for 7 months. Lanthanum...

Descripción completa

Detalles Bibliográficos
Autores principales: Tonooka, Akiko, Uda, Susumu, Tanaka, Hiroki, Yao, Atsushi, Uekusa, Toshimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Contents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581381/
https://www.ncbi.nlm.nih.gov/pubmed/26413283
http://dx.doi.org/10.1093/ckj/sfv062
_version_ 1782391555618766848
author Tonooka, Akiko
Uda, Susumu
Tanaka, Hiroki
Yao, Atsushi
Uekusa, Toshimasa
author_facet Tonooka, Akiko
Uda, Susumu
Tanaka, Hiroki
Yao, Atsushi
Uekusa, Toshimasa
author_sort Tonooka, Akiko
collection PubMed
description Lanthanum carbonate (LC) is an orally administered phosphate binder. Its absorption is generally thought to be minimal. We report here the case of an 81-year-old woman who underwent subtotal gastrectomy for gastric cancer after receiving hemodialysis for 1 year and taking LC for 7 months. Lanthanum phosphate compounds were found histologically in the gastric mucosa and a regional lymph node and confirmed by scanning and transmission electron microscopy–energy-dispersive X-ray spectroscopy. These findings suggest that lanthanum is absorbed in the stomach and transported via lymph flow. This observation could prove helpful in future investigation of lanthanum disposition.
format Online
Article
Text
id pubmed-4581381
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-45813812015-09-25 Possibility of lanthanum absorption in the stomach Tonooka, Akiko Uda, Susumu Tanaka, Hiroki Yao, Atsushi Uekusa, Toshimasa Clin Kidney J Contents Lanthanum carbonate (LC) is an orally administered phosphate binder. Its absorption is generally thought to be minimal. We report here the case of an 81-year-old woman who underwent subtotal gastrectomy for gastric cancer after receiving hemodialysis for 1 year and taking LC for 7 months. Lanthanum phosphate compounds were found histologically in the gastric mucosa and a regional lymph node and confirmed by scanning and transmission electron microscopy–energy-dispersive X-ray spectroscopy. These findings suggest that lanthanum is absorbed in the stomach and transported via lymph flow. This observation could prove helpful in future investigation of lanthanum disposition. Oxford University Press 2015-10 2015-07-16 /pmc/articles/PMC4581381/ /pubmed/26413283 http://dx.doi.org/10.1093/ckj/sfv062 Text en © The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Contents
Tonooka, Akiko
Uda, Susumu
Tanaka, Hiroki
Yao, Atsushi
Uekusa, Toshimasa
Possibility of lanthanum absorption in the stomach
title Possibility of lanthanum absorption in the stomach
title_full Possibility of lanthanum absorption in the stomach
title_fullStr Possibility of lanthanum absorption in the stomach
title_full_unstemmed Possibility of lanthanum absorption in the stomach
title_short Possibility of lanthanum absorption in the stomach
title_sort possibility of lanthanum absorption in the stomach
topic Contents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581381/
https://www.ncbi.nlm.nih.gov/pubmed/26413283
http://dx.doi.org/10.1093/ckj/sfv062
work_keys_str_mv AT tonookaakiko possibilityoflanthanumabsorptioninthestomach
AT udasusumu possibilityoflanthanumabsorptioninthestomach
AT tanakahiroki possibilityoflanthanumabsorptioninthestomach
AT yaoatsushi possibilityoflanthanumabsorptioninthestomach
AT uekusatoshimasa possibilityoflanthanumabsorptioninthestomach

Ejemplares similares