Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase

BACKGROUND: Avermectin and milbemycin are important 16-membered macrolides that have been widely used as pesticides in agriculture. However, the wide use of these pesticides inevitably causes serious drug resistance, it is therefore imperative to develop new avermectin and milbemycin analogs. The bi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ji, Yan, Yi-Jun, An, Jing, Huang, Sheng-Xiong, Wang, Xiang-Jing, Xiang, Wen-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581413/
https://www.ncbi.nlm.nih.gov/pubmed/26400541
http://dx.doi.org/10.1186/s12934-015-0337-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581413/
https://www.ncbi.nlm.nih.gov/pubmed/26400541
http://dx.doi.org/10.1186/s12934-015-0337-y

Ejemplares similares