MicroRNAs in urine are not biomarkers of multiple myeloma

BACKGROUND: In this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease. RESULTS: Analysis of urine samples was performed using Serum/Plasma Focus PCR MicroRNA Panel (Exiqon) and verified using individual TaqMan miRNA assays fo...

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Detalles Bibliográficos
Autores principales: Sedlaříková, Lenka, Bešše, Lenka, Novosadová, Soňa, Kubaczková, Veronika, Radová, Lenka, Staník, Michal, Krejčí, Marta, Hájek, Roman, Ševčíková, Sabina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581458/
https://www.ncbi.nlm.nih.gov/pubmed/26399230
http://dx.doi.org/10.1186/s12952-015-0035-7
Descripción
Sumario:BACKGROUND: In this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease. RESULTS: Analysis of urine samples was performed using Serum/Plasma Focus PCR MicroRNA Panel (Exiqon) and verified using individual TaqMan miRNA assays for qPCR. We found 20 deregulated microRNA (p < 0.05); for further validation, we chose 8 of them. Nevertheless, only differences in expression levels of miR-22-3p remained close to statistical significance. CONCLUSIONS: Our preliminary results did not confirm urine microRNA as a potential biomarker for multiple myeloma.

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