Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the generation of hyaluronan fragments of differe...

Descripción completa

Detalles Bibliográficos
Autores principales: Cyphert, Jaime M., Trempus, Carol S., Garantziotis, Stavros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581549/
https://www.ncbi.nlm.nih.gov/pubmed/26448754
http://dx.doi.org/10.1155/2015/563818
_version_ 1782391581242818560
author Cyphert, Jaime M.
Trempus, Carol S.
Garantziotis, Stavros
author_facet Cyphert, Jaime M.
Trempus, Carol S.
Garantziotis, Stavros
author_sort Cyphert, Jaime M.
collection PubMed
description Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the generation of hyaluronan fragments of different size and size-dependent differences in hyaluronan signaling as well as their downstream biological effects.
format Online
Article
Text
id pubmed-4581549
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-45815492015-10-07 Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology Cyphert, Jaime M. Trempus, Carol S. Garantziotis, Stavros Int J Cell Biol Review Article Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the generation of hyaluronan fragments of different size and size-dependent differences in hyaluronan signaling as well as their downstream biological effects. Hindawi Publishing Corporation 2015 2015-09-10 /pmc/articles/PMC4581549/ /pubmed/26448754 http://dx.doi.org/10.1155/2015/563818 Text en Copyright © 2015 Jaime M. Cyphert et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cyphert, Jaime M.
Trempus, Carol S.
Garantziotis, Stavros
Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
title Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
title_full Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
title_fullStr Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
title_full_unstemmed Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
title_short Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
title_sort size matters: molecular weight specificity of hyaluronan effects in cell biology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581549/
https://www.ncbi.nlm.nih.gov/pubmed/26448754
http://dx.doi.org/10.1155/2015/563818
work_keys_str_mv AT cyphertjaimem sizemattersmolecularweightspecificityofhyaluronaneffectsincellbiology
AT trempuscarols sizemattersmolecularweightspecificityofhyaluronaneffectsincellbiology
AT garantziotisstavros sizemattersmolecularweightspecificityofhyaluronaneffectsincellbiology

Ejemplares similares