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Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design

Glycogen branching enzyme 1 (GBE1) plays an essential role in glycogen biosynthesis by generating α-1,6-glucosidic branches from α-1,4-linked glucose chains, to increase solubility of the glycogen polymer. Mutations in the GBE1 gene lead to the heterogeneous early-onset glycogen storage disorder typ...

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Detalles Bibliográficos
Autores principales:	Froese, D. Sean, Michaeli, Amit, McCorvie, Thomas J., Krojer, Tobias, Sasi, Meitav, Melaev, Esther, Goldblum, Amiram, Zatsepin, Maria, Lossos, Alexander, Álvarez, Rafael, Escribá, Pablo V., Minassian, Berge A., von Delft, Frank, Kakhlon, Or, Yue, Wyatt W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581599/ https://www.ncbi.nlm.nih.gov/pubmed/26199317 http://dx.doi.org/10.1093/hmg/ddv280

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