Cargando…

TMPyP4, a Stabilizer of Nucleic Acid Secondary Structure, Is a Novel Acetylcholinesterase Inhibitor

The porphyrin compound, TMPyP4 (5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine), is widely used as a photosensitizer and a modulator of nucleic acid secondary structure stability. Our group recently showed in cultured cells and forebrain slice cultures that this compound can also down regulate exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fujiwara, Nana, Mazzola, Michael, Cai, Elizabeth, Wang, Meng, Cave, John W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581631/ https://www.ncbi.nlm.nih.gov/pubmed/26402367 http://dx.doi.org/10.1371/journal.pone.0139167

Ejemplares similares

Bcl-2 Promoter Sequence G-Quadruplex Interactions with Three Planar and Non-Planar Cationic Porphyrins: TMPyP4, TMPyP3, and TMPyP2
por: Le, Vu H., et al.
Publicado: (2013)

The Meta-Substituted Isomer of TMPyP Enables More Effective Photodynamic Bacterial Inactivation than Para-TMPyP In Vitro
por: Schulz, Sebastian, et al.
Publicado: (2022)

TMPyP Inhibits Amyloid-β Aggregation and Alleviates Amyloid-Induced Cytotoxicity
por: Fan, Yujuan, et al.
Publicado: (2017)

Pentose Phosphate Pathway Function Affects Tolerance to the G-Quadruplex Binder TMPyP4
por: Andrew, Elizabeth J., et al.
Publicado: (2013)

Stabilization of a G-Quadruplex from Unfolding by Replication Protein A Using Potassium and the Porphyrin TMPyP4
por: Prakash, Aishwarya, et al.
Publicado: (2011)

Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1
por: Artusi, Sara, et al.
Publicado: (2021)

The different biological effects of TMPyP4 and cisplatin in the inflammatory microenvironment of osteosarcoma are attributed to G‐quadruplex
por: Chen, Jianqiang, et al.
Publicado: (2021)

The Interactions of H(2)TMPyP, Analogues and Its Metal Complexes with DNA G-Quadruplexes—An Overview
por: Ramos, Catarina I. V., et al.
Publicado: (2021)

Telomerase Inhibitor TMPyP4 Alters Adhesion and Migration of Breast-Cancer Cells MCF7 and MDA-MB-231
por: Konieczna, Natalia, et al.
Publicado: (2019)

Antitumor activity of G-quadruplex-interactive agent TMPyP4 with photodynamic therapy in ovarian carcinoma cells
por: LIU, HONGLI, et al.
Publicado: (2014)

TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses
por: Zheng, Xiao-Hui, et al.
Publicado: (2016)

Characterization of a G-quadruplex from hepatitis B virus and its stabilization by binding TMPyP4, BRACO19 and PhenDC3
por: Molnár, Orsolya Réka, et al.
Publicado: (2021)

Mass spectrometric studies on effects of counter ions of TMPyP4 on binding to human telomeric DNA and RNA G-quadruplexes
por: Bai, Li-Ping, et al.
Publicado: (2014)

Genome-Wide Transcriptional Response of Mycobacterium smegmatis MC(2)155 to G-Quadruplex Ligands BRACO-19 and TMPyP4
por: Shitikov, Egor, et al.
Publicado: (2022)

Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4
por: Qin, Yong, et al.
Publicado: (2007)

The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene
por: Mori, Kohji, et al.
Publicado: (2021)

Photodynamic Activity of TMPyP4/TiO(2) Complex under Blue Light in Human Melanoma Cells: Potential for Cancer-Selective Therapy
por: Balas, Mihaela, et al.
Publicado: (2023)

The quadruplex r(CGG)(n) destabilizing cationic porphyrin TMPyP4 cooperates with hnRNPs to increase the translation efficiency of fragile X premutation mRNA
por: Ofer, Noa, et al.
Publicado: (2009)

Sensitive Hg(2+) Sensing via Quenching the Fluorescence of the Complex between Polythymine and 5,10,15,20-tetrakis(N-methyl-4-pyridyl) Porphyrin (TMPyP)
por: Wu, Daohong, et al.
Publicado: (2018)

Telomerase inhibitors TMPyP4 and thymoquinone decreased cell proliferation and induced cell death in the non-small cell lung cancer cell line LC-HK2, modifying the pattern of focal adhesion
por: Garnique, A.M.B., et al.
Publicado: (2023)

Binding of Telomestatin, TMPyP4, BSU6037, and BRACO19 to a Telomeric G-Quadruplex–Duplex Hybrid Probed by All-Atom Molecular Dynamics Simulations with Explicit Solvent
por: Sullivan, Holli-Joi, et al.
Publicado: (2018)

Regulation of tyrosine hydroxylase transcription by hnRNP K and DNA secondary structure
por: Banerjee, Kasturi, et al.
Publicado: (2014)

Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways
por: Lapi, Andrea, et al.
Publicado: (2001)

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis
por: Walczak-Nowicka, Łucja Justyna, et al.
Publicado: (2021)

NNDB: the nearest neighbor parameter database for predicting stability of nucleic acid secondary structure
por: Turner, Douglas H., et al.
Publicado: (2010)

Three (―)-cytisine derivatives and 1-hydroxyquinopimaric acid as acetylcholinesterase inhibitors
por: García-García, J. Daniel, et al.
Publicado: (2019)

Hydroxybenzoic Acids as Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies
por: Budryn, Grażyna, et al.
Publicado: (2022)

Intranasal administration of acetylcholinesterase inhibitors
por: Costantino, Henry R, et al.
Publicado: (2008)

Acetylcholinesterase inhibitors attenuate angiogenesis
por: Miyazaki, Ryohei, et al.
Publicado: (2012)

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
por: Čolović, Mirjana B, et al.
Publicado: (2013)

TMPYP4 exerted antitumor effects in human cervical cancer cells through activation of p38 mitogen-activated protein kinase
por: Cheng, Ming-Jun, et al.
Publicado: (2017)

An Electrophysiological and Proteomic Analysis of the Effects of the Superoxide Dismutase Mimetic, MnTMPyP, on Synaptic Signalling Post-Ischemia in Isolated Rat Hippocampal Slices
por: Puzio, Martina, et al.
Publicado: (2023)

Stability monitoring of some acetylcholinesterase reactivating drugs
por: Ram, Nazila, et al.
Publicado: (2011)

New Acetylcholinesterase Inhibitors for Alzheimer's Disease
por: Mehta, Mona, et al.
Publicado: (2012)

Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity
por: Pohanka, Miroslav
Publicado: (2014)

Musical Hallucinations Treated with Acetylcholinesterase Inhibitors
por: Blom, Jan Dirk, et al.
Publicado: (2015)

AML cells carrying NPM1 mutation are resistant to nucleophosmin displacement from nucleoli caused by the G-quadruplex ligand TmPyP4
por: De Cola, A, et al.
Publicado: (2014)

Loop dependence of the stability and dynamics of nucleic acid hairpins
por: Kuznetsov, Serguei V., et al.
Publicado: (2008)

Structure, stability and behaviour of nucleic acids in ionic liquids
por: Tateishi-Karimata, Hisae, et al.
Publicado: (2014)

QSAR analysis on tacrine-related acetylcholinesterase inhibitors
por: Wong, Kai Y, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jbloi03r84ludcft8dc5md86qp