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MicroRNA-34a induces apoptosis in PC12 cells by reducing B-cell lymphoma 2 and sirtuin-1 expression
MicroRNA-34a (miR-34a) is a direct target of p53 and was reported to induce cell cycle arrest, apoptosis and senescence. Inhibition of the NAD-dependent deacetylase sirtuin-1 (SIRT1) by miR-34a leads to an increase in acetylated p53, which promotes cell apoptosis. B-cell lymphoma 2 (Bcl-2) is also i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
D.A. Spandidos
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581806/ https://www.ncbi.nlm.nih.gov/pubmed/26252661 http://dx.doi.org/10.3892/mmr.2015.4185 |