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Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants
INTRODUCTION: This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs). METHODS: Subjects were infants who weighed 501–1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581837/ https://www.ncbi.nlm.nih.gov/pubmed/26402326 http://dx.doi.org/10.1371/journal.pone.0139014 |
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author | Maruyama, Hidehiko Yonemoto, Naohiro Kono, Yumi Kusuda, Satoshi Fujimura, Masanori |
author_facet | Maruyama, Hidehiko Yonemoto, Naohiro Kono, Yumi Kusuda, Satoshi Fujimura, Masanori |
author_sort | Maruyama, Hidehiko |
collection | PubMed |
description | INTRODUCTION: This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs). METHODS: Subjects were infants who weighed 501–1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003–2007). Patel’s exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI). RESULTS: In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4–11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60–3.62) and 1.81 (95%CI, 1.18–2.75), respectively, relative to the reference WGV score of 10. WGV scores ≥8 did not predict death or NDI. CONCLUSIONS: WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs. |
format | Online Article Text |
id | pubmed-4581837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45818372015-10-01 Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants Maruyama, Hidehiko Yonemoto, Naohiro Kono, Yumi Kusuda, Satoshi Fujimura, Masanori PLoS One Research Article INTRODUCTION: This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs). METHODS: Subjects were infants who weighed 501–1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003–2007). Patel’s exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI). RESULTS: In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4–11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60–3.62) and 1.81 (95%CI, 1.18–2.75), respectively, relative to the reference WGV score of 10. WGV scores ≥8 did not predict death or NDI. CONCLUSIONS: WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs. Public Library of Science 2015-09-24 /pmc/articles/PMC4581837/ /pubmed/26402326 http://dx.doi.org/10.1371/journal.pone.0139014 Text en © 2015 Maruyama et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Maruyama, Hidehiko Yonemoto, Naohiro Kono, Yumi Kusuda, Satoshi Fujimura, Masanori Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants |
title | Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants |
title_full | Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants |
title_fullStr | Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants |
title_full_unstemmed | Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants |
title_short | Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants |
title_sort | weight growth velocity and neurodevelopmental outcomes in extremely low birth weight infants |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581837/ https://www.ncbi.nlm.nih.gov/pubmed/26402326 http://dx.doi.org/10.1371/journal.pone.0139014 |
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