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Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants

INTRODUCTION: This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs). METHODS: Subjects were infants who weighed 501–1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan...

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Autores principales: Maruyama, Hidehiko, Yonemoto, Naohiro, Kono, Yumi, Kusuda, Satoshi, Fujimura, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581837/
https://www.ncbi.nlm.nih.gov/pubmed/26402326
http://dx.doi.org/10.1371/journal.pone.0139014
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author Maruyama, Hidehiko
Yonemoto, Naohiro
Kono, Yumi
Kusuda, Satoshi
Fujimura, Masanori
author_facet Maruyama, Hidehiko
Yonemoto, Naohiro
Kono, Yumi
Kusuda, Satoshi
Fujimura, Masanori
author_sort Maruyama, Hidehiko
collection PubMed
description INTRODUCTION: This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs). METHODS: Subjects were infants who weighed 501–1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003–2007). Patel’s exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI). RESULTS: In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4–11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60–3.62) and 1.81 (95%CI, 1.18–2.75), respectively, relative to the reference WGV score of 10. WGV scores ≥8 did not predict death or NDI. CONCLUSIONS: WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs.
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spelling pubmed-45818372015-10-01 Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants Maruyama, Hidehiko Yonemoto, Naohiro Kono, Yumi Kusuda, Satoshi Fujimura, Masanori PLoS One Research Article INTRODUCTION: This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs). METHODS: Subjects were infants who weighed 501–1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003–2007). Patel’s exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI). RESULTS: In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4–11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60–3.62) and 1.81 (95%CI, 1.18–2.75), respectively, relative to the reference WGV score of 10. WGV scores ≥8 did not predict death or NDI. CONCLUSIONS: WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs. Public Library of Science 2015-09-24 /pmc/articles/PMC4581837/ /pubmed/26402326 http://dx.doi.org/10.1371/journal.pone.0139014 Text en © 2015 Maruyama et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Maruyama, Hidehiko
Yonemoto, Naohiro
Kono, Yumi
Kusuda, Satoshi
Fujimura, Masanori
Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants
title Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants
title_full Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants
title_fullStr Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants
title_full_unstemmed Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants
title_short Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants
title_sort weight growth velocity and neurodevelopmental outcomes in extremely low birth weight infants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581837/
https://www.ncbi.nlm.nih.gov/pubmed/26402326
http://dx.doi.org/10.1371/journal.pone.0139014
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