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Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels?
PURPOSE: Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence. In Marfan syndrome, which is associated with mutations in Fibrillin-1, pelvic floor disorders are commonly observed. We hypot...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Continence Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582088/ https://www.ncbi.nlm.nih.gov/pubmed/26620898 http://dx.doi.org/10.5213/inj.2015.19.3.164 |
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author | Eser, Ayla Unlubilgin, Eylem Hizli, Fatih Acar, Muradiye Kamalak, Zeynep Kosus, Aydin Kosus, Nermin Hizli, Deniz Gunduz, Esra |
author_facet | Eser, Ayla Unlubilgin, Eylem Hizli, Fatih Acar, Muradiye Kamalak, Zeynep Kosus, Aydin Kosus, Nermin Hizli, Deniz Gunduz, Esra |
author_sort | Eser, Ayla |
collection | PubMed |
description | PURPOSE: Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence. In Marfan syndrome, which is associated with mutations in Fibrillin-1, pelvic floor disorders are commonly observed. We hypothesize that Fibrillin-1 gene expression is altered in pelvic organ prolapse. METHODS: Thirty women undergoing colporrhaphy or hysterectomy because of cystocele, rectocele, cystorectocele, or uterine prolapse were assigned to a pelvic prolapse study group, and thirty women undergone hysterectomy for nonpelvic prolapse conditions were assigned to a control group. Real-time polymerase chain reaction was conducted on vaginal tissue samples to measure the expression of Fibrillin-1. Expression levels were compared between study and control groups by Mann-Whitney U test with Bonferroni revision. RESULTS: Fibrillin-1 gene expression was not significantly lower in the study group than in the control group. Similarly, no significant correlation between Fibrillin-1 levels and grade of pelvic prolapse was found. Age over 40 years (P=0.018) and menopause (P=0.027) were both associated with reduced Fibrillin-1 levels in the pelvic prolapse group, whereas the delivery of babies weighing over 3,500 g at birth was associated with increased Fibrillin-1 expression (P=0.006). CONCLUSIONS: The results did not indicate a significant reduction in Fibrillin-1 gene expression in pelvic prolapse disorders; however, reduced Fibrillin-1 may contribute to increased pelvic organ prolapse risk with age and menopause. Increased Fibrillin-1 gene expression may be a compensatory mechanism in cases of delivery of babies with high birth weight. Further studies are needed for a better understanding of these observations. |
format | Online Article Text |
id | pubmed-4582088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korean Continence Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-45820882015-09-28 Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? Eser, Ayla Unlubilgin, Eylem Hizli, Fatih Acar, Muradiye Kamalak, Zeynep Kosus, Aydin Kosus, Nermin Hizli, Deniz Gunduz, Esra Int Neurourol J Original Article PURPOSE: Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence. In Marfan syndrome, which is associated with mutations in Fibrillin-1, pelvic floor disorders are commonly observed. We hypothesize that Fibrillin-1 gene expression is altered in pelvic organ prolapse. METHODS: Thirty women undergoing colporrhaphy or hysterectomy because of cystocele, rectocele, cystorectocele, or uterine prolapse were assigned to a pelvic prolapse study group, and thirty women undergone hysterectomy for nonpelvic prolapse conditions were assigned to a control group. Real-time polymerase chain reaction was conducted on vaginal tissue samples to measure the expression of Fibrillin-1. Expression levels were compared between study and control groups by Mann-Whitney U test with Bonferroni revision. RESULTS: Fibrillin-1 gene expression was not significantly lower in the study group than in the control group. Similarly, no significant correlation between Fibrillin-1 levels and grade of pelvic prolapse was found. Age over 40 years (P=0.018) and menopause (P=0.027) were both associated with reduced Fibrillin-1 levels in the pelvic prolapse group, whereas the delivery of babies weighing over 3,500 g at birth was associated with increased Fibrillin-1 expression (P=0.006). CONCLUSIONS: The results did not indicate a significant reduction in Fibrillin-1 gene expression in pelvic prolapse disorders; however, reduced Fibrillin-1 may contribute to increased pelvic organ prolapse risk with age and menopause. Increased Fibrillin-1 gene expression may be a compensatory mechanism in cases of delivery of babies with high birth weight. Further studies are needed for a better understanding of these observations. Korean Continence Society 2015-09 2015-09-22 /pmc/articles/PMC4582088/ /pubmed/26620898 http://dx.doi.org/10.5213/inj.2015.19.3.164 Text en Copyright © 2015 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Eser, Ayla Unlubilgin, Eylem Hizli, Fatih Acar, Muradiye Kamalak, Zeynep Kosus, Aydin Kosus, Nermin Hizli, Deniz Gunduz, Esra Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? |
title | Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? |
title_full | Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? |
title_fullStr | Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? |
title_full_unstemmed | Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? |
title_short | Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? |
title_sort | is there a relationship between pelvic organ prolapse and tissue fibrillin-1 levels? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582088/ https://www.ncbi.nlm.nih.gov/pubmed/26620898 http://dx.doi.org/10.5213/inj.2015.19.3.164 |
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