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Predictive factors for invasive intraductal papillary mucinous neoplasm of the pancreas
BACKGROUNDS/AIMS: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas has malignant potential. Predicting invasive IPMN has proven difficult and controversial. We tried to identify predictive factors for invasive IPMN. METHODS: Thirty six patients underwent resection for IPMN from Februar...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association of Hepato-Biliary-Pancreatic Surgery
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582470/ https://www.ncbi.nlm.nih.gov/pubmed/26421045 http://dx.doi.org/10.14701/kjhbps.2011.15.4.237 |
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author | Jun, Dae Young Kwon, Hyung Jun Kim, Sang Geol Kim, Sung Hi Chun, Jae Min Kwon, Young Bong Yoon, Kyung Jin Hwang, Yoon Jin Yun, Young Kook |
author_facet | Jun, Dae Young Kwon, Hyung Jun Kim, Sang Geol Kim, Sung Hi Chun, Jae Min Kwon, Young Bong Yoon, Kyung Jin Hwang, Yoon Jin Yun, Young Kook |
author_sort | Jun, Dae Young |
collection | PubMed |
description | BACKGROUNDS/AIMS: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas has malignant potential. Predicting invasive IPMN has proven difficult and controversial. We tried to identify predictive factors for invasive IPMN. METHODS: Thirty six patients underwent resection for IPMN from February 2001 to July 2011. Clinicopathological features including demographic, imaging, microscopic, and serological findings were retrospectively reviewed. Receiver operating characteristic (ROC) curve analysis was used to analyze sensitivity and specificity of all possible cut-off values for the diameter of the main pancreatic duct and mass size predicting invasive IPMN. Student t-test, chi-square test, and logistic regression were used for univariate and multivariate analysis. RESULTS: The mean age was 63.5±8.4 years. Males were more commonly affected (58.3% vs 41.7%). Pancreaticoduodenectomy was performed in 55.6% of patients, distal pancreatectomy in 36.1%, and central pancreatic resection in 8.3%. Non-invasive IPMNs were present in 80.6% (n=29), whereas invasive IPMNs were present in 19.4% (n=7). In univariate analysis, tumor location (p=0.036), Kuroda classification (p=0.048), mural nodule (p=0.016), and main duct dilatation (≥8 mm) (p=0.006) were statistically significant variables. ROC curve analysis showed that a value of 8 mm for the main duct dilatation and a value of 35 mm for the size of the mass lesion have 80% sensitivity and 75% specificity and 100% sensitivity and 82.6% specificity, respectively. However, in multivariate analysis, main ductal dilatation (≥8 mm) was identified to be the only independent factor for invasive IPMN (p=0.049). CONCLUSIONS: Main duct dilatation appears to be a useful indicator for predicting invasive IPMN. |
format | Online Article Text |
id | pubmed-4582470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Korean Association of Hepato-Biliary-Pancreatic Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-45824702015-09-29 Predictive factors for invasive intraductal papillary mucinous neoplasm of the pancreas Jun, Dae Young Kwon, Hyung Jun Kim, Sang Geol Kim, Sung Hi Chun, Jae Min Kwon, Young Bong Yoon, Kyung Jin Hwang, Yoon Jin Yun, Young Kook Korean J Hepatobiliary Pancreat Surg Original Article BACKGROUNDS/AIMS: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas has malignant potential. Predicting invasive IPMN has proven difficult and controversial. We tried to identify predictive factors for invasive IPMN. METHODS: Thirty six patients underwent resection for IPMN from February 2001 to July 2011. Clinicopathological features including demographic, imaging, microscopic, and serological findings were retrospectively reviewed. Receiver operating characteristic (ROC) curve analysis was used to analyze sensitivity and specificity of all possible cut-off values for the diameter of the main pancreatic duct and mass size predicting invasive IPMN. Student t-test, chi-square test, and logistic regression were used for univariate and multivariate analysis. RESULTS: The mean age was 63.5±8.4 years. Males were more commonly affected (58.3% vs 41.7%). Pancreaticoduodenectomy was performed in 55.6% of patients, distal pancreatectomy in 36.1%, and central pancreatic resection in 8.3%. Non-invasive IPMNs were present in 80.6% (n=29), whereas invasive IPMNs were present in 19.4% (n=7). In univariate analysis, tumor location (p=0.036), Kuroda classification (p=0.048), mural nodule (p=0.016), and main duct dilatation (≥8 mm) (p=0.006) were statistically significant variables. ROC curve analysis showed that a value of 8 mm for the main duct dilatation and a value of 35 mm for the size of the mass lesion have 80% sensitivity and 75% specificity and 100% sensitivity and 82.6% specificity, respectively. However, in multivariate analysis, main ductal dilatation (≥8 mm) was identified to be the only independent factor for invasive IPMN (p=0.049). CONCLUSIONS: Main duct dilatation appears to be a useful indicator for predicting invasive IPMN. Korean Association of Hepato-Biliary-Pancreatic Surgery 2011-11 2011-12-15 /pmc/articles/PMC4582470/ /pubmed/26421045 http://dx.doi.org/10.14701/kjhbps.2011.15.4.237 Text en Copyright © 2011 by The Korean Association of Hepato-Biliary-Pancreatic Surgery http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jun, Dae Young Kwon, Hyung Jun Kim, Sang Geol Kim, Sung Hi Chun, Jae Min Kwon, Young Bong Yoon, Kyung Jin Hwang, Yoon Jin Yun, Young Kook Predictive factors for invasive intraductal papillary mucinous neoplasm of the pancreas |
title | Predictive factors for invasive intraductal papillary mucinous neoplasm of the pancreas |
title_full | Predictive factors for invasive intraductal papillary mucinous neoplasm of the pancreas |
title_fullStr | Predictive factors for invasive intraductal papillary mucinous neoplasm of the pancreas |
title_full_unstemmed | Predictive factors for invasive intraductal papillary mucinous neoplasm of the pancreas |
title_short | Predictive factors for invasive intraductal papillary mucinous neoplasm of the pancreas |
title_sort | predictive factors for invasive intraductal papillary mucinous neoplasm of the pancreas |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582470/ https://www.ncbi.nlm.nih.gov/pubmed/26421045 http://dx.doi.org/10.14701/kjhbps.2011.15.4.237 |
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