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Theoretical modelling of epigenetically modified DNA sequences

We report herein a set of calculations designed to examine the effects of epigenetic modifications on the structure of DNA. The incorporation of methyl, hydroxymethyl, formyl and carboxy substituents at the 5-position of cytosine is shown to hardly affect the geometry of CG base pairs, but to result...

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Detalles Bibliográficos
Autores principales:	Carvalho, Alexandra Teresa Pires, Gouveia, Maria Leonor, Raju Kanna, Charan, Wärmländer, Sebastian K. T. S., Platts, Jamie, Kamerlin, Shina Caroline Lynn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000Research 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582758/ https://www.ncbi.nlm.nih.gov/pubmed/26448859 http://dx.doi.org/10.12688/f1000research.6148.2

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