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Conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex

Controlled semantic retrieval to words elicits co-activation of inferior frontal (IFG) and left posterior temporal cortex (pMTG), but research has not yet established (i) the distinct contributions of these regions or (ii) whether the same processes are recruited for non-verbal stimuli. Words have r...

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Autores principales: Krieger-Redwood, Katya, Teige, Catarina, Davey, James, Hymers, Mark, Jefferies, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582805/
https://www.ncbi.nlm.nih.gov/pubmed/25726898
http://dx.doi.org/10.1016/j.neuropsychologia.2015.02.030
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author Krieger-Redwood, Katya
Teige, Catarina
Davey, James
Hymers, Mark
Jefferies, Elizabeth
author_facet Krieger-Redwood, Katya
Teige, Catarina
Davey, James
Hymers, Mark
Jefferies, Elizabeth
author_sort Krieger-Redwood, Katya
collection PubMed
description Controlled semantic retrieval to words elicits co-activation of inferior frontal (IFG) and left posterior temporal cortex (pMTG), but research has not yet established (i) the distinct contributions of these regions or (ii) whether the same processes are recruited for non-verbal stimuli. Words have relatively flexible meanings – as a consequence, identifying the context that links two specific words is relatively demanding. In contrast, pictures are richer stimuli and their precise meaning is better specified by their visible features – however, not all of these features will be relevant to uncovering a given association, tapping selection/inhibition processes. To explore potential differences across modalities, we took a commonly-used manipulation of controlled retrieval demands, namely the identification of weak vs. strong associations, and compared word and picture versions. There were 4 key findings: (1) Regions of interest (ROIs) in posterior IFG (BA44) showed graded effects of modality (e.g., words>pictures in left BA44; pictures>words in right BA44). (2) An equivalent response was observed in left mid-IFG (BA45) across modalities, consistent with the multimodal semantic control deficits that typically follow LIFG lesions. (3) The anterior IFG (BA47) ROI showed a stronger response to verbal than pictorial associations, potentially reflecting a role for this region in establishing a meaningful context that can be used to direct semantic retrieval. (4) The left pMTG ROI also responded to difficulty across modalities yet showed a stronger response overall to verbal stimuli, helping to reconcile two distinct literatures that have implicated this site in semantic control and lexical-semantic access respectively. We propose that left anterior IFG and pMTG work together to maintain a meaningful context that shapes ongoing semantic processing, and that this process is more strongly taxed by word than picture associations.
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spelling pubmed-45828052015-10-27 Conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex Krieger-Redwood, Katya Teige, Catarina Davey, James Hymers, Mark Jefferies, Elizabeth Neuropsychologia Article Controlled semantic retrieval to words elicits co-activation of inferior frontal (IFG) and left posterior temporal cortex (pMTG), but research has not yet established (i) the distinct contributions of these regions or (ii) whether the same processes are recruited for non-verbal stimuli. Words have relatively flexible meanings – as a consequence, identifying the context that links two specific words is relatively demanding. In contrast, pictures are richer stimuli and their precise meaning is better specified by their visible features – however, not all of these features will be relevant to uncovering a given association, tapping selection/inhibition processes. To explore potential differences across modalities, we took a commonly-used manipulation of controlled retrieval demands, namely the identification of weak vs. strong associations, and compared word and picture versions. There were 4 key findings: (1) Regions of interest (ROIs) in posterior IFG (BA44) showed graded effects of modality (e.g., words>pictures in left BA44; pictures>words in right BA44). (2) An equivalent response was observed in left mid-IFG (BA45) across modalities, consistent with the multimodal semantic control deficits that typically follow LIFG lesions. (3) The anterior IFG (BA47) ROI showed a stronger response to verbal than pictorial associations, potentially reflecting a role for this region in establishing a meaningful context that can be used to direct semantic retrieval. (4) The left pMTG ROI also responded to difficulty across modalities yet showed a stronger response overall to verbal stimuli, helping to reconcile two distinct literatures that have implicated this site in semantic control and lexical-semantic access respectively. We propose that left anterior IFG and pMTG work together to maintain a meaningful context that shapes ongoing semantic processing, and that this process is more strongly taxed by word than picture associations. Pergamon Press 2015-09 /pmc/articles/PMC4582805/ /pubmed/25726898 http://dx.doi.org/10.1016/j.neuropsychologia.2015.02.030 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Krieger-Redwood, Katya
Teige, Catarina
Davey, James
Hymers, Mark
Jefferies, Elizabeth
Conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex
title Conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex
title_full Conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex
title_fullStr Conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex
title_full_unstemmed Conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex
title_short Conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex
title_sort conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582805/
https://www.ncbi.nlm.nih.gov/pubmed/25726898
http://dx.doi.org/10.1016/j.neuropsychologia.2015.02.030
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