Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium

BACKGROUND: Arrest of metastasising lung cancer cells to the brain microvasculature maybe mediated by interactions between ligands on circulating tumour cells and endothelial E-selectin adhesion molecules; a process likely to be regulated by the endothelial glycocalyx. Using human cerebral microvasc...

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Detalles Bibliográficos
Autores principales: Rai, Srijana, Nejadhamzeeigilani, Zaynab, Gutowski, Nicholas J., Whatmore, Jacqueline L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582832/
https://www.ncbi.nlm.nih.gov/pubmed/26407999
http://dx.doi.org/10.1186/s13046-015-0223-9

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