Cargando…

Intrinsically disordered caldesmon binds calmodulin via the “buttons on a string” mechanism

We show here that chicken gizzard caldesmon (CaD) and its C-terminal domain (residues 636–771, CaD(136)) are intrinsically disordered proteins. The computational and experimental analyses of the wild type CaD(136) and series of its single tryptophan mutants (W674A, W707A, and W737A) and a double try...

Descripción completa

Detalles Bibliográficos
Autores principales:	Permyakov, Sergei E., Permyakov, Eugene A., Uversky, Vladimir N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582948/ https://www.ncbi.nlm.nih.gov/pubmed/26417545 http://dx.doi.org/10.7717/peerj.1265

Ejemplares similares

What Is Parvalbumin for?
por: Permyakov, Eugene A., et al.
Publicado: (2022)

Calcium-Bound S100P Protein Is a Promiscuous Binding Partner of the Four-Helical Cytokines
por: Kazakov, Alexey S., et al.
Publicado: (2022)

Papain-like cysteine proteinase zone (PCP-zone) and PCP structural catalytic core (PCP-SCC) of enzymes with cysteine proteinase fold
por: Denessiouk, Konstantin, et al.
Publicado: (2020)

Structural and functional significance of the amino acid differences Val(35)Thr, Ser(46)Ala, Asn(65)Ser, and Ala(94)Ser in 3C-like proteinases from SARS-CoV-2 and SARS-CoV
por: Denesyuk, Alexander I., et al.
Publicado: (2021)

Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome
por: Coelho Ribeiro, Maria de Lourdes, et al.
Publicado: (2013)

Interferon Beta Activity Is Modulated via Binding of Specific S100 Proteins
por: Kazakov, Alexey S., et al.
Publicado: (2020)

Two Structural Motifs within Canonical EF-Hand Calcium-Binding Domains Identify Five Different Classes of Calcium Buffers and Sensors
por: Denessiouk, Konstantin, et al.
Publicado: (2014)

System Approach for Building of Calcium-Binding Sites in Proteins
por: Denesyuk, Alexander I., et al.
Publicado: (2020)

α-Lactalbumin, Amazing Calcium-Binding Protein
por: Permyakov, Eugene A.
Publicado: (2020)

Intrinsic Disorder in the Human Tear Proteome
por: Taylor Gonzalez, David J., et al.
Publicado: (2023)

Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its Activity
por: Kazakov, Alexey S., et al.
Publicado: (2022)

Erythropoietin Interacts with Specific S100 Proteins
por: Kazakov, Alexey S., et al.
Publicado: (2022)

Interaction of S100A6 Protein with the Four-Helical Cytokines
por: Kazakov, Alexey S., et al.
Publicado: (2023)

Interferon-β Activity Is Affected by S100B Protein
por: Kazakov, Alexey S., et al.
Publicado: (2022)

Calmodulin: The switch button of calcium signaling
por: Yang, Chiu-Fen, et al.
Publicado: (2021)

Experimental Insight into the Structural and Functional Roles of the ‘Black’ and ‘Gray’ Clusters in Recoverin, a Calcium Binding Protein with Four EF-Hand Motifs
por: Permyakov, Sergey E., et al.
Publicado: (2019)

Ca(2+)/Sr(2+) Selectivity in Calcium-Sensing Receptor (CaSR): Implications for Strontium’s Anti-Osteoporosis Effect
por: Cheshmedzhieva, Diana, et al.
Publicado: (2021)

Regulation of mTORC1 by lysosomal calcium and calmodulin
por: Li, Ruo-Jing, et al.
Publicado: (2016)

Overexpression of human fibroblast caldesmon fragment containing actin- , Ca++/calmodulin-, and tropomyosin-binding domains stabilizes endogenous tropomyosin and microfilaments
Publicado: (1994)

Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II
por: Bhattacharyya, Moitrayee, et al.
Publicado: (2016)

Metal-binding polymorphism in late embryogenesis abundant protein AtLEA4-5, an intrinsically disordered protein
por: French-Pacheco, Leidys, et al.
Publicado: (2018)

Structure and stability of recombinant bovine odorant-binding protein: II. Unfolding of the monomeric forms
por: Stepanenko, Olga V., et al.
Publicado: (2016)

Strontium Binding to α-Parvalbumin, a Canonical Calcium-Binding Protein of the “EF-Hand” Family
por: Vologzhannikova, Alisa A., et al.
Publicado: (2021)

Structure and stability of recombinant bovine odorant-binding protein: I. Design and analysis of monomeric mutants
por: Stepanenko, Olga V., et al.
Publicado: (2016)

Synergetic Effect of Recoverin and Calmodulin on Regulation of Rhodopsin Kinase
por: Grigoriev, Ilya I., et al.
Publicado: (2012)

Structure and stability of recombinant bovine odorant-binding protein: III. Peculiarities of the wild type bOBP unfolding in crowded milieu
por: Stepanenko, Olga V., et al.
Publicado: (2016)

Calmodulin-controlled spatial decoding of oscillatory Ca(2+) signals by calcineurin
por: Mehta, Sohum, et al.
Publicado: (2014)

Expression, Purification, and Characterization of Interleukin-11 Orthologues
por: Sokolov, Andrei S., et al.
Publicado: (2016)

Association between intrinsic disorder and serine/threonine phosphorylation in Mycobacterium tuberculosis
por: Singh, Gajinder Pal
Publicado: (2015)

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation
por: Zhang, Zhengjian, et al.
Publicado: (2015)

Derivative of Extremophilic 50S Ribosomal Protein L35Ae as an Alternative Protein Scaffold
por: Lomonosova, Anna V., et al.
Publicado: (2017)

Exploring the mechanisms by which camel lactoferrin can kill Salmonella enterica serovar typhimurium and Shigella sonnei
por: Almehdar, Hussein A., et al.
Publicado: (2023)

Single-step purification of intrinsic protein complexes in Saccharomyces cerevisiae using regenerable calmodulin resin
por: Bhojoo, Urvi, et al.
Publicado: (2018)

The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins
por: Uversky, Vladimir N
Publicado: (2013)

Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders
por: Uversky, Vladimir N.
Publicado: (2015)

Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation
por: Smith, F Donelson, et al.
Publicado: (2013)

Natural resources to control COVID-19: could lactoferrin amend SARS-CoV-2 infectivity?
por: Mattar, Ehab H., et al.
Publicado: (2021)

Extremophilic 50S Ribosomal RNA-Binding Protein L35Ae as a Basis for Engineering of an Alternative Protein Scaffold
por: Lomonosova, Anna V., et al.
Publicado: (2015)

Chemical synthesis of peptidoglycan mimetic–disaccharide-tetrapeptide conjugate and its hydrolysis by bacteriophage T5, RB43 and RB49 L-alanyl-D-glutamate peptidases
por: Azev, Viatcheslav, et al.
Publicado: (2021)

The Highly Conservative Cysteine of Oncomodulin as a Feasible Redox Sensor
por: Vologzhannikova, Alisa A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ehvvidbv0d6tmamoodcftdq82t