Cargando…
p53 activated by AND gate genetic circuit under radiation and hypoxia for targeted cancer gene therapy
Radio-activated gene therapy has been developed as a novel therapeutic strategy against cancer; however, expression of therapeutic gene in peritumoral tissues will result in unacceptable toxicity to normal cells. To restrict gene expression in targeted tumor mass, we used hypoxia and radiation toler...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Ltd
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582985/ https://www.ncbi.nlm.nih.gov/pubmed/26177264 http://dx.doi.org/10.1111/cas.12739 |