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Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial
BACKGROUND: Low grade inflammation and oxidative stress are the key factors in the pathogenesis and development of diabetes and its complications. Coenzyme Q10 (CoQ10) is known as an antioxidant and has a vital role in generation of cellular energy providing. This study was undertaken to evaluate th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583053/ https://www.ncbi.nlm.nih.gov/pubmed/26413493 http://dx.doi.org/10.1186/s40200-014-0081-6 |
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author | Zahedi, Hoda Eghtesadi, Shahryar Seifirad, Soroush Rezaee, Neshat Shidfar, Farzad Heydari, Iraj Golestan, Banafsheh Jazayeri, Shima |
author_facet | Zahedi, Hoda Eghtesadi, Shahryar Seifirad, Soroush Rezaee, Neshat Shidfar, Farzad Heydari, Iraj Golestan, Banafsheh Jazayeri, Shima |
author_sort | Zahedi, Hoda |
collection | PubMed |
description | BACKGROUND: Low grade inflammation and oxidative stress are the key factors in the pathogenesis and development of diabetes and its complications. Coenzyme Q10 (CoQ10) is known as an antioxidant and has a vital role in generation of cellular energy providing. This study was undertaken to evaluate the effects of CoQ10 supplementation on lipid profiles and glycemic controls in patients with diabetes. METHODS: Fifty patients with diabetes were randomly allocated into two groups to receive either 150 mg CoQ10 or placebo daily for 12 weeks. Before and after supplementation, fasting venous blood samples were collected and lipid profiles containing triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) and glycemic indices comprising of fasting plasma glucose (FPG), insulin and hemoglobin A(1)C (HbA(1)C) were measured. Insulin resistance was calculated using HOMA-IR index. RESULTS: Forty patients completed the study. After intervention FPG and HbA(1)C were significantly lower in the CoQ10 group compared to the placebo group, but there were no significant differences in serum insulin and HOMA-IR between the two groups. Although total cholesterol did not change in the Q10 group after supplementation, triglyceride and HDL-C significantly decreased and LDL-C significantly increased in the CoQ10 group. CONCLUSION: The present study showed that treatment with Q10 may improve glycemic control with no favorable effects on lipid profiles in type 2 patients with diabetes. TRIAL REGISTRATION: IRCT registry number: IRCT138806102394N1 |
format | Online Article Text |
id | pubmed-4583053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45830532015-09-26 Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial Zahedi, Hoda Eghtesadi, Shahryar Seifirad, Soroush Rezaee, Neshat Shidfar, Farzad Heydari, Iraj Golestan, Banafsheh Jazayeri, Shima J Diabetes Metab Disord Research Article BACKGROUND: Low grade inflammation and oxidative stress are the key factors in the pathogenesis and development of diabetes and its complications. Coenzyme Q10 (CoQ10) is known as an antioxidant and has a vital role in generation of cellular energy providing. This study was undertaken to evaluate the effects of CoQ10 supplementation on lipid profiles and glycemic controls in patients with diabetes. METHODS: Fifty patients with diabetes were randomly allocated into two groups to receive either 150 mg CoQ10 or placebo daily for 12 weeks. Before and after supplementation, fasting venous blood samples were collected and lipid profiles containing triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) and glycemic indices comprising of fasting plasma glucose (FPG), insulin and hemoglobin A(1)C (HbA(1)C) were measured. Insulin resistance was calculated using HOMA-IR index. RESULTS: Forty patients completed the study. After intervention FPG and HbA(1)C were significantly lower in the CoQ10 group compared to the placebo group, but there were no significant differences in serum insulin and HOMA-IR between the two groups. Although total cholesterol did not change in the Q10 group after supplementation, triglyceride and HDL-C significantly decreased and LDL-C significantly increased in the CoQ10 group. CONCLUSION: The present study showed that treatment with Q10 may improve glycemic control with no favorable effects on lipid profiles in type 2 patients with diabetes. TRIAL REGISTRATION: IRCT registry number: IRCT138806102394N1 BioMed Central 2014-07-25 /pmc/articles/PMC4583053/ /pubmed/26413493 http://dx.doi.org/10.1186/s40200-014-0081-6 Text en Copyright © 2014 Zahedi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zahedi, Hoda Eghtesadi, Shahryar Seifirad, Soroush Rezaee, Neshat Shidfar, Farzad Heydari, Iraj Golestan, Banafsheh Jazayeri, Shima Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial |
title | Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial |
title_full | Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial |
title_fullStr | Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial |
title_full_unstemmed | Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial |
title_short | Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial |
title_sort | effects of coq10 supplementation on lipid profiles and glycemic control in patients with type 2 diabetes: a randomized, double blind, placebo-controlled trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583053/ https://www.ncbi.nlm.nih.gov/pubmed/26413493 http://dx.doi.org/10.1186/s40200-014-0081-6 |
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