Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

In vitro preclinical models for the assessment of drug-induced liver injury (DILI) are usually based on cryopreserved primary human hepatocytes (cPHH) or human hepatic tumor-derived cell lines; however, it is unclear how well such cell models reflect the normal function of liver cells. The physiolog...

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Detalles Bibliográficos
Autores principales: Sison-Young, Rowena L. C., Mitsa, Dimitra, Jenkins, Rosalind E., Mottram, David, Alexandre, Eliane, Richert, Lysiane, Aerts, Hélène, Weaver, Richard J., Jones, Robert P., Johann, Esther, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Christopher E. P., Kitteringham, Neil R., Park, B. Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Proteomic Evaluation of Cellular Liver Toxicity Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583060/
https://www.ncbi.nlm.nih.gov/pubmed/26160117
http://dx.doi.org/10.1093/toxsci/kfv136

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