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Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications
Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583113/ https://www.ncbi.nlm.nih.gov/pubmed/26425089 http://dx.doi.org/10.2147/IJN.S84307 |
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author | Balaji, Arunpandian Jaganathan, Saravana Kumar Supriyanto, Eko Muhamad, Ida Idayu Khudzari, Ahmad Zahran Md |
author_facet | Balaji, Arunpandian Jaganathan, Saravana Kumar Supriyanto, Eko Muhamad, Ida Idayu Khudzari, Ahmad Zahran Md |
author_sort | Balaji, Arunpandian |
collection | PubMed |
description | Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera, a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera-induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera-glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants. |
format | Online Article Text |
id | pubmed-4583113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45831132015-09-30 Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications Balaji, Arunpandian Jaganathan, Saravana Kumar Supriyanto, Eko Muhamad, Ida Idayu Khudzari, Ahmad Zahran Md Int J Nanomedicine Original Research Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera, a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera-induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera-glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants. Dove Medical Press 2015-09-18 /pmc/articles/PMC4583113/ /pubmed/26425089 http://dx.doi.org/10.2147/IJN.S84307 Text en © 2015 Balaji et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Balaji, Arunpandian Jaganathan, Saravana Kumar Supriyanto, Eko Muhamad, Ida Idayu Khudzari, Ahmad Zahran Md Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications |
title | Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications |
title_full | Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications |
title_fullStr | Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications |
title_full_unstemmed | Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications |
title_short | Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications |
title_sort | microwave-assisted fibrous decoration of mpe surface utilizing aloe vera extract for tissue engineering applications |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583113/ https://www.ncbi.nlm.nih.gov/pubmed/26425089 http://dx.doi.org/10.2147/IJN.S84307 |
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