Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma

Fifty percent of cutaneous melanomas are driven by activated BRAF (V600E), but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there is a pressing need to identify the major mechanisms of intrinsic and adaptive resistance and devel...

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Detalles Bibliográficos
Autores principales: Capaldo, Brian J., Roller, Devin, Axelrod, Mark J., Koeppel, Alex F., Petricoin, Emanuel F., Slingluff, Craig L., Weber, Michael J., Mackey, Aaron J., Gioeli, Daniel, Bekiranov, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583389/
https://www.ncbi.nlm.nih.gov/pubmed/26405815
http://dx.doi.org/10.1371/journal.pone.0138210

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