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Zn(II)-curc targets p53 in thyroid cancer cells

TP53 mutation is a common event in many cancers, including thyroid carcinoma. Defective p53 activity promotes cancer resistance to therapies and a more malignant phenotype, acquiring oncogenic functions. Rescuing the function of mutant p53 (mutp53) protein is an attractive anticancer therapeutic str...

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Detalles Bibliográficos
Autores principales: GARUFI, ALESSIA, D'ORAZI, VALERIO, CRISPINI, ALESSANDRA, D'ORAZI, GABRIELLA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583539/
https://www.ncbi.nlm.nih.gov/pubmed/26314369
http://dx.doi.org/10.3892/ijo.2015.3125