DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation

Viral infection activates the transcription factors NF-κB and IRF3, which contribute to the induction of type I interferons (IFNs) and cellular antiviral responses. Protein kinases play a critical role in various signaling pathways by phosphorylating their substrates. Here, we identified dual-specif...

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Detalles Bibliográficos
Autores principales: An, Tai, Li, Shu, Pan, Wei, Tien, Po, Zhong, Bo, Shu, Hong-Bing, Wu, Shuwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583546/
https://www.ncbi.nlm.nih.gov/pubmed/26407194
http://dx.doi.org/10.1371/journal.ppat.1005179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583546/
https://www.ncbi.nlm.nih.gov/pubmed/26407194
http://dx.doi.org/10.1371/journal.ppat.1005179

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