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MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions
Studies in the cardiovascular research field have demonstrated the vital roles of microRNAs for proper cardiovascular development and functional maintenance. The involvement of aberrant microRNA expression leading to ontogenesis of cardiovascular diseases lends further support of the regulatory role...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583634/ https://www.ncbi.nlm.nih.gov/pubmed/26484225 http://dx.doi.org/10.1016/j.gdata.2015.05.020 |
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author | Chen, Yei-Tsung Liew, Oi-Wah Richards, Arthur Mark |
author_facet | Chen, Yei-Tsung Liew, Oi-Wah Richards, Arthur Mark |
author_sort | Chen, Yei-Tsung |
collection | PubMed |
description | Studies in the cardiovascular research field have demonstrated the vital roles of microRNAs for proper cardiovascular development and functional maintenance. The involvement of aberrant microRNA expression leading to ontogenesis of cardiovascular diseases lends further support of the regulatory role of microRNAs in heart function. Hypoxic insult is one of the major factors that trigger downstream signal cascades which contribute to the pathogenesis of hypoxic/ischemic-related heart diseases. Here, we report the microRNA expression profile in human cardiac-derived cells subjected to 120-h hypoxic treatment. By comparing with the normoxic control state, we identified microRNAs differentially expressed in cardiac cells subjected to hypoxic challenge. MicroRNA microarray data are available at NCBI under the GEO accession number, GSE55387. |
format | Online Article Text |
id | pubmed-4583634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-45836342015-10-19 MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions Chen, Yei-Tsung Liew, Oi-Wah Richards, Arthur Mark Genom Data Data in Brief Studies in the cardiovascular research field have demonstrated the vital roles of microRNAs for proper cardiovascular development and functional maintenance. The involvement of aberrant microRNA expression leading to ontogenesis of cardiovascular diseases lends further support of the regulatory role of microRNAs in heart function. Hypoxic insult is one of the major factors that trigger downstream signal cascades which contribute to the pathogenesis of hypoxic/ischemic-related heart diseases. Here, we report the microRNA expression profile in human cardiac-derived cells subjected to 120-h hypoxic treatment. By comparing with the normoxic control state, we identified microRNAs differentially expressed in cardiac cells subjected to hypoxic challenge. MicroRNA microarray data are available at NCBI under the GEO accession number, GSE55387. Elsevier 2015-05-29 /pmc/articles/PMC4583634/ /pubmed/26484225 http://dx.doi.org/10.1016/j.gdata.2015.05.020 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Data in Brief Chen, Yei-Tsung Liew, Oi-Wah Richards, Arthur Mark MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions |
title | MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions |
title_full | MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions |
title_fullStr | MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions |
title_full_unstemmed | MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions |
title_short | MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions |
title_sort | microrna expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions |
topic | Data in Brief |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583634/ https://www.ncbi.nlm.nih.gov/pubmed/26484225 http://dx.doi.org/10.1016/j.gdata.2015.05.020 |
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