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Identifying type 1 diabetes candidate genes by DNA microarray analysis of islet-specific CD4 + T cells
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease resulting from the destruction of insulin-producing pancreatic beta cells and is fatal unless treated with insulin. During the last four decades, multiple insulin-dependent diabetes (Idd) susceptibility/resistance loci that regulate T1D d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583664/ https://www.ncbi.nlm.nih.gov/pubmed/26484253 http://dx.doi.org/10.1016/j.gdata.2015.05.041 |
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author | Berry, Gregory J. Frielle, Christine Brucklacher, Robert M. Salzberg, Anna C. Waldner, Hanspeter |
author_facet | Berry, Gregory J. Frielle, Christine Brucklacher, Robert M. Salzberg, Anna C. Waldner, Hanspeter |
author_sort | Berry, Gregory J. |
collection | PubMed |
description | Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease resulting from the destruction of insulin-producing pancreatic beta cells and is fatal unless treated with insulin. During the last four decades, multiple insulin-dependent diabetes (Idd) susceptibility/resistance loci that regulate T1D development have been identified in humans and non-obese diabetic (NOD) mice, an established animal model for T1D. However, the exact mechanisms by which these loci confer diabetes risk and the identity of the causative genes remain largely elusive. To identify genes and molecular mechanisms that control the function of diabetogenic T cells, we conducted DNA microarray analysis in islet-specific CD4 + T cells from BDC2.5 TCR transgenic NOD mice that contain the Idd9 locus from T1D-susceptible NOD mice or T1D-resistant C57BL/10 mice. Here we describe in detail the contents and analyses for these gene expression data associated with our previous study [1]. Gene expression data are available at the Gene Expression Omnibus (GEO) repository from the National Center for Biotechnology Information (accession number GSE64674). |
format | Online Article Text |
id | pubmed-4583664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-45836642015-10-19 Identifying type 1 diabetes candidate genes by DNA microarray analysis of islet-specific CD4 + T cells Berry, Gregory J. Frielle, Christine Brucklacher, Robert M. Salzberg, Anna C. Waldner, Hanspeter Genom Data Data in Brief Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease resulting from the destruction of insulin-producing pancreatic beta cells and is fatal unless treated with insulin. During the last four decades, multiple insulin-dependent diabetes (Idd) susceptibility/resistance loci that regulate T1D development have been identified in humans and non-obese diabetic (NOD) mice, an established animal model for T1D. However, the exact mechanisms by which these loci confer diabetes risk and the identity of the causative genes remain largely elusive. To identify genes and molecular mechanisms that control the function of diabetogenic T cells, we conducted DNA microarray analysis in islet-specific CD4 + T cells from BDC2.5 TCR transgenic NOD mice that contain the Idd9 locus from T1D-susceptible NOD mice or T1D-resistant C57BL/10 mice. Here we describe in detail the contents and analyses for these gene expression data associated with our previous study [1]. Gene expression data are available at the Gene Expression Omnibus (GEO) repository from the National Center for Biotechnology Information (accession number GSE64674). Elsevier 2015-06-14 /pmc/articles/PMC4583664/ /pubmed/26484253 http://dx.doi.org/10.1016/j.gdata.2015.05.041 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Data in Brief Berry, Gregory J. Frielle, Christine Brucklacher, Robert M. Salzberg, Anna C. Waldner, Hanspeter Identifying type 1 diabetes candidate genes by DNA microarray analysis of islet-specific CD4 + T cells |
title | Identifying type 1 diabetes candidate genes by DNA microarray analysis of islet-specific CD4 + T cells |
title_full | Identifying type 1 diabetes candidate genes by DNA microarray analysis of islet-specific CD4 + T cells |
title_fullStr | Identifying type 1 diabetes candidate genes by DNA microarray analysis of islet-specific CD4 + T cells |
title_full_unstemmed | Identifying type 1 diabetes candidate genes by DNA microarray analysis of islet-specific CD4 + T cells |
title_short | Identifying type 1 diabetes candidate genes by DNA microarray analysis of islet-specific CD4 + T cells |
title_sort | identifying type 1 diabetes candidate genes by dna microarray analysis of islet-specific cd4 + t cells |
topic | Data in Brief |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583664/ https://www.ncbi.nlm.nih.gov/pubmed/26484253 http://dx.doi.org/10.1016/j.gdata.2015.05.041 |
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