Cargando…

Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival

Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumour-associated molecules according to individual tumour b...

Descripción completa

Detalles Bibliográficos
Autores principales: Martins, Sandra F., Amorim, Ricardo, Mota, Sílvia Coelho, Costa, Luís, Pardal, Fernando, Rodrigues, Mesquita, Longatto-Filho, Adhemar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584044/
https://www.ncbi.nlm.nih.gov/pubmed/26448927
http://dx.doi.org/10.1155/2015/131685
_version_ 1782391929006194688
author Martins, Sandra F.
Amorim, Ricardo
Mota, Sílvia Coelho
Costa, Luís
Pardal, Fernando
Rodrigues, Mesquita
Longatto-Filho, Adhemar
author_facet Martins, Sandra F.
Amorim, Ricardo
Mota, Sílvia Coelho
Costa, Luís
Pardal, Fernando
Rodrigues, Mesquita
Longatto-Filho, Adhemar
author_sort Martins, Sandra F.
collection PubMed
description Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumour-associated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained by Ki-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.
format Online
Article
Text
id pubmed-4584044
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-45840442015-10-07 Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival Martins, Sandra F. Amorim, Ricardo Mota, Sílvia Coelho Costa, Luís Pardal, Fernando Rodrigues, Mesquita Longatto-Filho, Adhemar Biomed Res Int Research Article Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumour-associated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained by Ki-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division. Hindawi Publishing Corporation 2015 2015-09-13 /pmc/articles/PMC4584044/ /pubmed/26448927 http://dx.doi.org/10.1155/2015/131685 Text en Copyright © 2015 Sandra F. Martins et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Martins, Sandra F.
Amorim, Ricardo
Mota, Sílvia Coelho
Costa, Luís
Pardal, Fernando
Rodrigues, Mesquita
Longatto-Filho, Adhemar
Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival
title Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival
title_full Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival
title_fullStr Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival
title_full_unstemmed Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival
title_short Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival
title_sort ki-67 expression in crc lymph node metastasis does not predict survival
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584044/
https://www.ncbi.nlm.nih.gov/pubmed/26448927
http://dx.doi.org/10.1155/2015/131685
work_keys_str_mv AT martinssandraf ki67expressionincrclymphnodemetastasisdoesnotpredictsurvival
AT amorimricardo ki67expressionincrclymphnodemetastasisdoesnotpredictsurvival
AT motasilviacoelho ki67expressionincrclymphnodemetastasisdoesnotpredictsurvival
AT costaluis ki67expressionincrclymphnodemetastasisdoesnotpredictsurvival
AT pardalfernando ki67expressionincrclymphnodemetastasisdoesnotpredictsurvival
AT rodriguesmesquita ki67expressionincrclymphnodemetastasisdoesnotpredictsurvival
AT longattofilhoadhemar ki67expressionincrclymphnodemetastasisdoesnotpredictsurvival