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Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses

Background and Aim. Pancreatic juice cytology (PJC) is considered optimal for differentially diagnosing pancreatic masses, but the accuracy of PJC ranges from 46.7% to 93.0%. The aim of this study was to evaluate the clinical impact of measuring the KL-6 concentration of pancreatic juice for diagnos...

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Autores principales: Matsumoto, Kazuya, Takeda, Yohei, Harada, Kenichi, Onoyama, Takumi, Kawata, Soichiro, Horie, Yasushi, Sakamoto, Teruhisa, Ueki, Masaru, Miura, Norimasa, Murawaki, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584219/
https://www.ncbi.nlm.nih.gov/pubmed/26451373
http://dx.doi.org/10.1155/2015/528304
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author Matsumoto, Kazuya
Takeda, Yohei
Harada, Kenichi
Onoyama, Takumi
Kawata, Soichiro
Horie, Yasushi
Sakamoto, Teruhisa
Ueki, Masaru
Miura, Norimasa
Murawaki, Yoshikazu
author_facet Matsumoto, Kazuya
Takeda, Yohei
Harada, Kenichi
Onoyama, Takumi
Kawata, Soichiro
Horie, Yasushi
Sakamoto, Teruhisa
Ueki, Masaru
Miura, Norimasa
Murawaki, Yoshikazu
author_sort Matsumoto, Kazuya
collection PubMed
description Background and Aim. Pancreatic juice cytology (PJC) is considered optimal for differentially diagnosing pancreatic masses, but the accuracy of PJC ranges from 46.7% to 93.0%. The aim of this study was to evaluate the clinical impact of measuring the KL-6 concentration of pancreatic juice for diagnosing pancreatic masses. Methods. PJC and the KL-6 concentration measurements of pancreatic juice were performed for 70 consecutive patients with pancreatic masses (39 malignancies and 31 benign). Results. The average KL-6 concentration of pancreatic juice was significantly higher for pancreatic ductal adenocarcinomas (PDACs) (167.7 ± 396.1 U/mL) and intraductal papillary mucinous carcinomas (IPMCs) (86.9 ± 21.1 U/mL) than for pancreatic inflammatory lesions (17.5 ± 15.7 U/mL, P = 0.034) and intraductal papillary mucinous neoplasms (14.4 ± 2.0 U/mL, P = 0.026), respectively. When the cut-off level of the KL-6 concentration of pancreatic juice was 16 U/mL, the sensitivity, specificity, and accuracy of the KL-6 concentration of pancreatic juice alone were 79.5%, 64.5%, and 72.9%, respectively. Adding the KL-6 concentration of pancreatic juice to PJC when making a diagnosis caused the values of sensitivity and accuracy of PJC to increase by 15.3% (P = 0.025) and 8.5% (P = 0.048), respectively. Conclusions. The KL-6 concentration of pancreatic juice may be as useful as PJC for diagnosing PDACs.
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spelling pubmed-45842192015-10-08 Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses Matsumoto, Kazuya Takeda, Yohei Harada, Kenichi Onoyama, Takumi Kawata, Soichiro Horie, Yasushi Sakamoto, Teruhisa Ueki, Masaru Miura, Norimasa Murawaki, Yoshikazu Biomed Res Int Research Article Background and Aim. Pancreatic juice cytology (PJC) is considered optimal for differentially diagnosing pancreatic masses, but the accuracy of PJC ranges from 46.7% to 93.0%. The aim of this study was to evaluate the clinical impact of measuring the KL-6 concentration of pancreatic juice for diagnosing pancreatic masses. Methods. PJC and the KL-6 concentration measurements of pancreatic juice were performed for 70 consecutive patients with pancreatic masses (39 malignancies and 31 benign). Results. The average KL-6 concentration of pancreatic juice was significantly higher for pancreatic ductal adenocarcinomas (PDACs) (167.7 ± 396.1 U/mL) and intraductal papillary mucinous carcinomas (IPMCs) (86.9 ± 21.1 U/mL) than for pancreatic inflammatory lesions (17.5 ± 15.7 U/mL, P = 0.034) and intraductal papillary mucinous neoplasms (14.4 ± 2.0 U/mL, P = 0.026), respectively. When the cut-off level of the KL-6 concentration of pancreatic juice was 16 U/mL, the sensitivity, specificity, and accuracy of the KL-6 concentration of pancreatic juice alone were 79.5%, 64.5%, and 72.9%, respectively. Adding the KL-6 concentration of pancreatic juice to PJC when making a diagnosis caused the values of sensitivity and accuracy of PJC to increase by 15.3% (P = 0.025) and 8.5% (P = 0.048), respectively. Conclusions. The KL-6 concentration of pancreatic juice may be as useful as PJC for diagnosing PDACs. Hindawi Publishing Corporation 2015 2015-09-14 /pmc/articles/PMC4584219/ /pubmed/26451373 http://dx.doi.org/10.1155/2015/528304 Text en Copyright © 2015 Kazuya Matsumoto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Matsumoto, Kazuya
Takeda, Yohei
Harada, Kenichi
Onoyama, Takumi
Kawata, Soichiro
Horie, Yasushi
Sakamoto, Teruhisa
Ueki, Masaru
Miura, Norimasa
Murawaki, Yoshikazu
Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses
title Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses
title_full Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses
title_fullStr Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses
title_full_unstemmed Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses
title_short Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses
title_sort clinical impact of the kl-6 concentration of pancreatic juice for diagnosing pancreatic masses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584219/
https://www.ncbi.nlm.nih.gov/pubmed/26451373
http://dx.doi.org/10.1155/2015/528304
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