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Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses
Background and Aim. Pancreatic juice cytology (PJC) is considered optimal for differentially diagnosing pancreatic masses, but the accuracy of PJC ranges from 46.7% to 93.0%. The aim of this study was to evaluate the clinical impact of measuring the KL-6 concentration of pancreatic juice for diagnos...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584219/ https://www.ncbi.nlm.nih.gov/pubmed/26451373 http://dx.doi.org/10.1155/2015/528304 |
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author | Matsumoto, Kazuya Takeda, Yohei Harada, Kenichi Onoyama, Takumi Kawata, Soichiro Horie, Yasushi Sakamoto, Teruhisa Ueki, Masaru Miura, Norimasa Murawaki, Yoshikazu |
author_facet | Matsumoto, Kazuya Takeda, Yohei Harada, Kenichi Onoyama, Takumi Kawata, Soichiro Horie, Yasushi Sakamoto, Teruhisa Ueki, Masaru Miura, Norimasa Murawaki, Yoshikazu |
author_sort | Matsumoto, Kazuya |
collection | PubMed |
description | Background and Aim. Pancreatic juice cytology (PJC) is considered optimal for differentially diagnosing pancreatic masses, but the accuracy of PJC ranges from 46.7% to 93.0%. The aim of this study was to evaluate the clinical impact of measuring the KL-6 concentration of pancreatic juice for diagnosing pancreatic masses. Methods. PJC and the KL-6 concentration measurements of pancreatic juice were performed for 70 consecutive patients with pancreatic masses (39 malignancies and 31 benign). Results. The average KL-6 concentration of pancreatic juice was significantly higher for pancreatic ductal adenocarcinomas (PDACs) (167.7 ± 396.1 U/mL) and intraductal papillary mucinous carcinomas (IPMCs) (86.9 ± 21.1 U/mL) than for pancreatic inflammatory lesions (17.5 ± 15.7 U/mL, P = 0.034) and intraductal papillary mucinous neoplasms (14.4 ± 2.0 U/mL, P = 0.026), respectively. When the cut-off level of the KL-6 concentration of pancreatic juice was 16 U/mL, the sensitivity, specificity, and accuracy of the KL-6 concentration of pancreatic juice alone were 79.5%, 64.5%, and 72.9%, respectively. Adding the KL-6 concentration of pancreatic juice to PJC when making a diagnosis caused the values of sensitivity and accuracy of PJC to increase by 15.3% (P = 0.025) and 8.5% (P = 0.048), respectively. Conclusions. The KL-6 concentration of pancreatic juice may be as useful as PJC for diagnosing PDACs. |
format | Online Article Text |
id | pubmed-4584219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45842192015-10-08 Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses Matsumoto, Kazuya Takeda, Yohei Harada, Kenichi Onoyama, Takumi Kawata, Soichiro Horie, Yasushi Sakamoto, Teruhisa Ueki, Masaru Miura, Norimasa Murawaki, Yoshikazu Biomed Res Int Research Article Background and Aim. Pancreatic juice cytology (PJC) is considered optimal for differentially diagnosing pancreatic masses, but the accuracy of PJC ranges from 46.7% to 93.0%. The aim of this study was to evaluate the clinical impact of measuring the KL-6 concentration of pancreatic juice for diagnosing pancreatic masses. Methods. PJC and the KL-6 concentration measurements of pancreatic juice were performed for 70 consecutive patients with pancreatic masses (39 malignancies and 31 benign). Results. The average KL-6 concentration of pancreatic juice was significantly higher for pancreatic ductal adenocarcinomas (PDACs) (167.7 ± 396.1 U/mL) and intraductal papillary mucinous carcinomas (IPMCs) (86.9 ± 21.1 U/mL) than for pancreatic inflammatory lesions (17.5 ± 15.7 U/mL, P = 0.034) and intraductal papillary mucinous neoplasms (14.4 ± 2.0 U/mL, P = 0.026), respectively. When the cut-off level of the KL-6 concentration of pancreatic juice was 16 U/mL, the sensitivity, specificity, and accuracy of the KL-6 concentration of pancreatic juice alone were 79.5%, 64.5%, and 72.9%, respectively. Adding the KL-6 concentration of pancreatic juice to PJC when making a diagnosis caused the values of sensitivity and accuracy of PJC to increase by 15.3% (P = 0.025) and 8.5% (P = 0.048), respectively. Conclusions. The KL-6 concentration of pancreatic juice may be as useful as PJC for diagnosing PDACs. Hindawi Publishing Corporation 2015 2015-09-14 /pmc/articles/PMC4584219/ /pubmed/26451373 http://dx.doi.org/10.1155/2015/528304 Text en Copyright © 2015 Kazuya Matsumoto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Matsumoto, Kazuya Takeda, Yohei Harada, Kenichi Onoyama, Takumi Kawata, Soichiro Horie, Yasushi Sakamoto, Teruhisa Ueki, Masaru Miura, Norimasa Murawaki, Yoshikazu Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses |
title | Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses |
title_full | Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses |
title_fullStr | Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses |
title_full_unstemmed | Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses |
title_short | Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses |
title_sort | clinical impact of the kl-6 concentration of pancreatic juice for diagnosing pancreatic masses |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584219/ https://www.ncbi.nlm.nih.gov/pubmed/26451373 http://dx.doi.org/10.1155/2015/528304 |
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