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Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate

The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch aceta...

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Detalles Bibliográficos
Autores principales: Jesus, Douglas Rossi, Barbosa, Lorena Neris, Prando, Thiago Bruno Lima, Martins, Leonardo Franco, Gasparotto, Francielli, Guedes, Karla Moraes Rocha, Dragunski, Douglas Cardoso, Lourenço, Emerson Luiz Botelho, Dalsenter, Paulo Roberto, Gasparotto Junior, Arquimedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584237/
https://www.ncbi.nlm.nih.gov/pubmed/26451154
http://dx.doi.org/10.1155/2015/390416
Descripción
Sumario:The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity in Wistar rats, indicating possible safety of this biofilm.