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Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters

Intravascular catheters are among the most commonly inserted medical devices and they are known to cause a large number of catheter related bloodstream infections (BSIs). Biofilms are associated with many chronic infections due to the aggregation of microorganisms. One of these organisms is the fung...

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Autores principales: Akbari, Freshta, Kjellerup, Birthe Veno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584267/
https://www.ncbi.nlm.nih.gov/pubmed/26131615
http://dx.doi.org/10.3390/pathogens4030457
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author Akbari, Freshta
Kjellerup, Birthe Veno
author_facet Akbari, Freshta
Kjellerup, Birthe Veno
author_sort Akbari, Freshta
collection PubMed
description Intravascular catheters are among the most commonly inserted medical devices and they are known to cause a large number of catheter related bloodstream infections (BSIs). Biofilms are associated with many chronic infections due to the aggregation of microorganisms. One of these organisms is the fungus Candida albicans. It has shown to be one of the leading causes of catheter-related BSIs. The presence of biofilm on intravascular catheters provide increased tolerance against antimicrobial treatments, thus alternative treatment strategies are sought. Traditionally, many strategies, such as application of combined antimicrobials, addition of antifungals, and removal of catheters, have been practiced, but they were not successful in eradicating BSIs. Since these fungal infections can result in significant morbidity, mortality, and increased healthcare cost, other promising preventive strategies, including antimicrobial lock therapy, chelating agents, alcohol, and biofilm disruptors, have been applied. In this review, current success and failure of these new approaches, and a comparison with the previous strategies are discussed in order to understand which preventative treatment is the most effective in controlling the catheter-related BSIs.
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spelling pubmed-45842672015-10-05 Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters Akbari, Freshta Kjellerup, Birthe Veno Pathogens Review Intravascular catheters are among the most commonly inserted medical devices and they are known to cause a large number of catheter related bloodstream infections (BSIs). Biofilms are associated with many chronic infections due to the aggregation of microorganisms. One of these organisms is the fungus Candida albicans. It has shown to be one of the leading causes of catheter-related BSIs. The presence of biofilm on intravascular catheters provide increased tolerance against antimicrobial treatments, thus alternative treatment strategies are sought. Traditionally, many strategies, such as application of combined antimicrobials, addition of antifungals, and removal of catheters, have been practiced, but they were not successful in eradicating BSIs. Since these fungal infections can result in significant morbidity, mortality, and increased healthcare cost, other promising preventive strategies, including antimicrobial lock therapy, chelating agents, alcohol, and biofilm disruptors, have been applied. In this review, current success and failure of these new approaches, and a comparison with the previous strategies are discussed in order to understand which preventative treatment is the most effective in controlling the catheter-related BSIs. MDPI 2015-06-29 /pmc/articles/PMC4584267/ /pubmed/26131615 http://dx.doi.org/10.3390/pathogens4030457 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Akbari, Freshta
Kjellerup, Birthe Veno
Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters
title Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters
title_full Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters
title_fullStr Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters
title_full_unstemmed Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters
title_short Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters
title_sort elimination of bloodstream infections associated with candida albicans biofilm in intravascular catheters
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584267/
https://www.ncbi.nlm.nih.gov/pubmed/26131615
http://dx.doi.org/10.3390/pathogens4030457
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