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Interleukin 17-Mediated Host Defense against Candida albicans
Candida albicans is part of the normal microbiota in most healthy individuals. However, it can cause opportunistic infections if host defenses are breached, with symptoms ranging from superficial lesions to severe systemic disease. The study of rare congenital defects in patients with chronic mucocu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584276/ https://www.ncbi.nlm.nih.gov/pubmed/26274976 http://dx.doi.org/10.3390/pathogens4030606 |
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author | Sparber, Florian LeibundGut-Landmann, Salomé |
author_facet | Sparber, Florian LeibundGut-Landmann, Salomé |
author_sort | Sparber, Florian |
collection | PubMed |
description | Candida albicans is part of the normal microbiota in most healthy individuals. However, it can cause opportunistic infections if host defenses are breached, with symptoms ranging from superficial lesions to severe systemic disease. The study of rare congenital defects in patients with chronic mucocutaneous candidiasis led to the identification of interleukin-17 (IL-17) as a key factor in host defense against mucosal fungal infection. Experimental infections in mice confirmed the critical role of IL-17 in mucocutaneous immunity against C. albicans. Research on mouse models has also contributed importantly to our current understanding of the regulation of IL-17 production by different cellular sources and its effector functions in distinct tissues. In this review, we highlight recent findings on IL-17-mediated immunity against C. albicans in mouse and man. |
format | Online Article Text |
id | pubmed-4584276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45842762015-10-05 Interleukin 17-Mediated Host Defense against Candida albicans Sparber, Florian LeibundGut-Landmann, Salomé Pathogens Review Candida albicans is part of the normal microbiota in most healthy individuals. However, it can cause opportunistic infections if host defenses are breached, with symptoms ranging from superficial lesions to severe systemic disease. The study of rare congenital defects in patients with chronic mucocutaneous candidiasis led to the identification of interleukin-17 (IL-17) as a key factor in host defense against mucosal fungal infection. Experimental infections in mice confirmed the critical role of IL-17 in mucocutaneous immunity against C. albicans. Research on mouse models has also contributed importantly to our current understanding of the regulation of IL-17 production by different cellular sources and its effector functions in distinct tissues. In this review, we highlight recent findings on IL-17-mediated immunity against C. albicans in mouse and man. MDPI 2015-08-12 /pmc/articles/PMC4584276/ /pubmed/26274976 http://dx.doi.org/10.3390/pathogens4030606 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sparber, Florian LeibundGut-Landmann, Salomé Interleukin 17-Mediated Host Defense against Candida albicans |
title | Interleukin 17-Mediated Host Defense against Candida albicans |
title_full | Interleukin 17-Mediated Host Defense against Candida albicans |
title_fullStr | Interleukin 17-Mediated Host Defense against Candida albicans |
title_full_unstemmed | Interleukin 17-Mediated Host Defense against Candida albicans |
title_short | Interleukin 17-Mediated Host Defense against Candida albicans |
title_sort | interleukin 17-mediated host defense against candida albicans |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584276/ https://www.ncbi.nlm.nih.gov/pubmed/26274976 http://dx.doi.org/10.3390/pathogens4030606 |
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