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Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection
Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584279/ https://www.ncbi.nlm.nih.gov/pubmed/26308062 http://dx.doi.org/10.3390/pathogens4030639 |
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author | Rizzetto, Lisa Weil, Tobias Cavalieri, Duccio |
author_facet | Rizzetto, Lisa Weil, Tobias Cavalieri, Duccio |
author_sort | Rizzetto, Lisa |
collection | PubMed |
description | Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens. During the past decade, the host immune response to Candida was dissected in depth, highlighting the essential role of C-type lectin receptors, especially regarding the power of the Dectins’ family in discriminating between the tolerated yeast-like form of Candida and its invading counterpart, the hyphae. This review focuses on the immuno-modulatory properties of the Candida morphologies and their specific interactions with the host innate immune system in different body surfaces. |
format | Online Article Text |
id | pubmed-4584279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45842792015-10-05 Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection Rizzetto, Lisa Weil, Tobias Cavalieri, Duccio Pathogens Review Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens. During the past decade, the host immune response to Candida was dissected in depth, highlighting the essential role of C-type lectin receptors, especially regarding the power of the Dectins’ family in discriminating between the tolerated yeast-like form of Candida and its invading counterpart, the hyphae. This review focuses on the immuno-modulatory properties of the Candida morphologies and their specific interactions with the host innate immune system in different body surfaces. MDPI 2015-08-21 /pmc/articles/PMC4584279/ /pubmed/26308062 http://dx.doi.org/10.3390/pathogens4030639 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rizzetto, Lisa Weil, Tobias Cavalieri, Duccio Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection |
title | Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection |
title_full | Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection |
title_fullStr | Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection |
title_full_unstemmed | Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection |
title_short | Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection |
title_sort | systems level dissection of candida recognition by dectins: a matter of fungal morphology and site of infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584279/ https://www.ncbi.nlm.nih.gov/pubmed/26308062 http://dx.doi.org/10.3390/pathogens4030639 |
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