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Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection

Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens...

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Detalles Bibliográficos
Autores principales: Rizzetto, Lisa, Weil, Tobias, Cavalieri, Duccio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584279/
https://www.ncbi.nlm.nih.gov/pubmed/26308062
http://dx.doi.org/10.3390/pathogens4030639
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author Rizzetto, Lisa
Weil, Tobias
Cavalieri, Duccio
author_facet Rizzetto, Lisa
Weil, Tobias
Cavalieri, Duccio
author_sort Rizzetto, Lisa
collection PubMed
description Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens. During the past decade, the host immune response to Candida was dissected in depth, highlighting the essential role of C-type lectin receptors, especially regarding the power of the Dectins’ family in discriminating between the tolerated yeast-like form of Candida and its invading counterpart, the hyphae. This review focuses on the immuno-modulatory properties of the Candida morphologies and their specific interactions with the host innate immune system in different body surfaces.
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spelling pubmed-45842792015-10-05 Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection Rizzetto, Lisa Weil, Tobias Cavalieri, Duccio Pathogens Review Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens. During the past decade, the host immune response to Candida was dissected in depth, highlighting the essential role of C-type lectin receptors, especially regarding the power of the Dectins’ family in discriminating between the tolerated yeast-like form of Candida and its invading counterpart, the hyphae. This review focuses on the immuno-modulatory properties of the Candida morphologies and their specific interactions with the host innate immune system in different body surfaces. MDPI 2015-08-21 /pmc/articles/PMC4584279/ /pubmed/26308062 http://dx.doi.org/10.3390/pathogens4030639 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rizzetto, Lisa
Weil, Tobias
Cavalieri, Duccio
Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection
title Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection
title_full Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection
title_fullStr Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection
title_full_unstemmed Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection
title_short Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection
title_sort systems level dissection of candida recognition by dectins: a matter of fungal morphology and site of infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584279/
https://www.ncbi.nlm.nih.gov/pubmed/26308062
http://dx.doi.org/10.3390/pathogens4030639
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