Nucleosome Dancing at the Tempo of Histone Tail Acetylation

The impact of histone acetylation on transcription was revealed over 50 years ago by Allfrey and colleagues. However, it took decades for an understanding of the fine mechanism by which this posttranslational modification affects chromatin structure and promotes transcription. Here, we review breakt...

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Detalles Bibliográficos
Autores principales: Galvani, Angélique, Thiriet, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584320/
https://www.ncbi.nlm.nih.gov/pubmed/26184324
http://dx.doi.org/10.3390/genes6030607
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author Galvani, Angélique
Thiriet, Christophe
author_facet Galvani, Angélique
Thiriet, Christophe
author_sort Galvani, Angélique
collection PubMed
description The impact of histone acetylation on transcription was revealed over 50 years ago by Allfrey and colleagues. However, it took decades for an understanding of the fine mechanism by which this posttranslational modification affects chromatin structure and promotes transcription. Here, we review breakthroughs linking histone tail acetylation, histone dynamics, and transcription. We also discuss the histone exchange during transcription and highlight the important function of a pool of non-chromatinized histones in chromatin dynamics.
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spelling pubmed-45843202015-10-05 Nucleosome Dancing at the Tempo of Histone Tail Acetylation Galvani, Angélique Thiriet, Christophe Genes (Basel) Review The impact of histone acetylation on transcription was revealed over 50 years ago by Allfrey and colleagues. However, it took decades for an understanding of the fine mechanism by which this posttranslational modification affects chromatin structure and promotes transcription. Here, we review breakthroughs linking histone tail acetylation, histone dynamics, and transcription. We also discuss the histone exchange during transcription and highlight the important function of a pool of non-chromatinized histones in chromatin dynamics. MDPI 2015-07-15 /pmc/articles/PMC4584320/ /pubmed/26184324 http://dx.doi.org/10.3390/genes6030607 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Galvani, Angélique
Thiriet, Christophe
Nucleosome Dancing at the Tempo of Histone Tail Acetylation
title Nucleosome Dancing at the Tempo of Histone Tail Acetylation
title_full Nucleosome Dancing at the Tempo of Histone Tail Acetylation
title_fullStr Nucleosome Dancing at the Tempo of Histone Tail Acetylation
title_full_unstemmed Nucleosome Dancing at the Tempo of Histone Tail Acetylation
title_short Nucleosome Dancing at the Tempo of Histone Tail Acetylation
title_sort nucleosome dancing at the tempo of histone tail acetylation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584320/
https://www.ncbi.nlm.nih.gov/pubmed/26184324
http://dx.doi.org/10.3390/genes6030607
work_keys_str_mv AT galvaniangelique nucleosomedancingatthetempoofhistonetailacetylation
AT thirietchristophe nucleosomedancingatthetempoofhistonetailacetylation

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