Rural-urban differences in the clinico-pathologic profiles of Jamaican men with prostate cancer

BACKGROUND: Prostate cancer causes the highest number of cancer-related deaths in Jamaican men. It is not known whether rural-dwelling men present with worse disease than urban-dwelling men at initial presentation. Since rural and urban-dwelling Jamaicans are predominantly of African descent and generally similar in respect of racial composition, if any significant variation in initial presentation were found, it would suggest that these are likely due to differences in awareness, access to care, and screening patterns. METHODS: The medical records of rural and urban-dwelling patients with prostate cancer were compared. Patients’ age at presentation, initial prostate-specific antigen level, digital rectal examination findings, biopsy Gleason scores and initial treatment received were compared using bivariate and logistic regression analyses. RESULTS: In unadjusted analyses rural-dwelling men were older compared to urban-dwelling men (72 years versus 68.5 years, p = 0.035), had higher median PSA values (22.9 ng/ml versus 18 ng/ml, p = 0.001), higher local tumour stage (65.2 % versus 34.8 % T3 disease; 73.7 % versus 26.3 % T4 disease; p = 0.005), higher mean Gleason scores (p = 0.048) and more non-curative initial treatments. Local tumour stage was the only statistically significant difference between rural and urban-dwelling men in logistic regression analysis with rural-dwelling men having a 70 % higher risk of locally-advanced disease (OR = 1.70, 95 % CI: 1.03-2.79; p = 0.038). CONCLUSION: Rural-dwelling men presented with more advanced prostate cancer compared to urban-dwelling men. As both rural and urban-dwelling men are of predominant African descent it is likely that these differences are due to differences in access to care, screening practice and awareness of the disease.