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The Murray collection of pre-antibiotic era Enterobacteriacae: a unique research resource
Studies of historical isolates inform on the evolution and emergence of important pathogens and phenotypes, including antimicrobial resistance. Crucial to studying antimicrobial resistance are isolates that predate the widespread clinical use of antimicrobials. The Murray collection of several hundr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584482/ https://www.ncbi.nlm.nih.gov/pubmed/26411565 http://dx.doi.org/10.1186/s13073-015-0222-7 |
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author | Baker, Kate S. Burnett, Edward McGregor, Hannah Deheer-Graham, Ana Boinett, Christine Langridge, Gemma C. Wailan, Alexander M. Cain, Amy K. Thomson, Nicholas R. Russell, Julie E. Parkhill, Julian |
author_facet | Baker, Kate S. Burnett, Edward McGregor, Hannah Deheer-Graham, Ana Boinett, Christine Langridge, Gemma C. Wailan, Alexander M. Cain, Amy K. Thomson, Nicholas R. Russell, Julie E. Parkhill, Julian |
author_sort | Baker, Kate S. |
collection | PubMed |
description | Studies of historical isolates inform on the evolution and emergence of important pathogens and phenotypes, including antimicrobial resistance. Crucial to studying antimicrobial resistance are isolates that predate the widespread clinical use of antimicrobials. The Murray collection of several hundred bacterial strains of pre-antibiotic era Enterobacteriaceae is an invaluable resource of historical strains from important pathogen groups. Studies performed on the Collection to date merely exemplify its potential, which will only be realised through the continued effort of many scientific groups. To enable that aim, we announce the public availability of the Murray collection through the National Collection of Type Cultures, and present associated metadata with whole genome sequence data for over half of the strains. Using this information we verify the metadata for the collection with regard to subgroup designations, equivalence groupings and plasmid content. We also present genomic analyses of population structure and determinants of mobilisable antimicrobial resistance to aid strain selection in future studies. This represents an invaluable public resource for the study of these important pathogen groups and the emergence and evolution of antimicrobial resistance. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13073-015-0222-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4584482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45844822015-09-29 The Murray collection of pre-antibiotic era Enterobacteriacae: a unique research resource Baker, Kate S. Burnett, Edward McGregor, Hannah Deheer-Graham, Ana Boinett, Christine Langridge, Gemma C. Wailan, Alexander M. Cain, Amy K. Thomson, Nicholas R. Russell, Julie E. Parkhill, Julian Genome Med Correspondance Studies of historical isolates inform on the evolution and emergence of important pathogens and phenotypes, including antimicrobial resistance. Crucial to studying antimicrobial resistance are isolates that predate the widespread clinical use of antimicrobials. The Murray collection of several hundred bacterial strains of pre-antibiotic era Enterobacteriaceae is an invaluable resource of historical strains from important pathogen groups. Studies performed on the Collection to date merely exemplify its potential, which will only be realised through the continued effort of many scientific groups. To enable that aim, we announce the public availability of the Murray collection through the National Collection of Type Cultures, and present associated metadata with whole genome sequence data for over half of the strains. Using this information we verify the metadata for the collection with regard to subgroup designations, equivalence groupings and plasmid content. We also present genomic analyses of population structure and determinants of mobilisable antimicrobial resistance to aid strain selection in future studies. This represents an invaluable public resource for the study of these important pathogen groups and the emergence and evolution of antimicrobial resistance. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13073-015-0222-7) contains supplementary material, which is available to authorized users. BioMed Central 2015-09-28 /pmc/articles/PMC4584482/ /pubmed/26411565 http://dx.doi.org/10.1186/s13073-015-0222-7 Text en © Baker et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Correspondance Baker, Kate S. Burnett, Edward McGregor, Hannah Deheer-Graham, Ana Boinett, Christine Langridge, Gemma C. Wailan, Alexander M. Cain, Amy K. Thomson, Nicholas R. Russell, Julie E. Parkhill, Julian The Murray collection of pre-antibiotic era Enterobacteriacae: a unique research resource |
title | The Murray collection of pre-antibiotic era Enterobacteriacae: a unique research resource |
title_full | The Murray collection of pre-antibiotic era Enterobacteriacae: a unique research resource |
title_fullStr | The Murray collection of pre-antibiotic era Enterobacteriacae: a unique research resource |
title_full_unstemmed | The Murray collection of pre-antibiotic era Enterobacteriacae: a unique research resource |
title_short | The Murray collection of pre-antibiotic era Enterobacteriacae: a unique research resource |
title_sort | murray collection of pre-antibiotic era enterobacteriacae: a unique research resource |
topic | Correspondance |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584482/ https://www.ncbi.nlm.nih.gov/pubmed/26411565 http://dx.doi.org/10.1186/s13073-015-0222-7 |
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